Studies On The Chemical Constituents Of Caesalpinia Millettii Hook. Et Arn. Livistona Chinensis (Jacq.) R. Br And Souliea Vaginata (Maxim.) Franch

In this doctoral dissertation, the phytochemical and pharmacologicalstudies were carried out on the medicinal plants of caesaIpinia, millettii Hook. et Arn,Livistona chinensis (Jacq.) R. Br and Souliea vaginata (Maxim.) Franch.Meanwhile, the advances in the recent research of chemical constituents andpharmacological activities of the genus of caesalpinia, millettii Hook. et Arn. werereviewed.Twenty-four(Mc-1～Mc-24) were isolated from the acetone extract of the aerialparts of caesalpinia, millettii Hook. et Arn. by using the modern chromatographytechniques. And on the basis of the spectroscopic analysis and chemical methods,their structures were determined as follows: Eucomin (Mc-1), 8-Methoxybonducellin(Mc-2), Intricatinol (Mc-3), Bonducellin (Mc-4), 8-Methoxyisobonducellin (Mc-5),Hyperoside (Mc-6), tamarixetin 3-O-(6"-O-E-caffeoyl)-β-D-Galactopyranoside(Mc-7), Isoliquiritigenin (Mc-8), Liquiritigenin (Mc-9), Hentriacontane (Mc-10),Tritriacontane (Mc-11), Nonacosyl alcohol (Mc-12), Docosyl caffeate (Mc-13),β-sitosterol (Mc-14), Daucosterol (Mc-15), Bergenin (Mc-16), 11-O-galloylbergenin(Mc-17), Resveratrol (Mc-18), Gallic acid (Mc-19), Digallic acid (Mc-20),Tetragallic acid (Mc-21), Tetragallicin (Mc-22), Ellagic acid (Mc-23), Methyl gallate(Mc-24)。In the twenty-four compounds, Mc-5, Mc-7, Mc-21 and Mc-22 were newcompounds, Mc-1～Mc-4, Mc-6, Mc-8～Mc-13, Mc-16, Mc-17, Mc-20, Mc-23 and intemetMc-24 were isolated from this genus for the first time, Mc-14, Mc-15, Mc-18, Mc-19were isolated from this plant for the first time. Cytotoxicity of eight compounds wereresearched with MTT methods, tamarixetin 3-O-(6"-O-E-caffeoyl)-β-D-Galactopyranoside (Mc-7) and gallic acid (Mc-19) showed strong cytotoxicityactivity. Five flavones were qualified on the caesalpinia, millettii Hook. et Arn. ofdifferent resources. Chemical constituents and pharmacological activity of H. annuuswere reviewed.Fifteen compounds were isolated from the stem of Livistona chinensis (Jacq.)R. Br with various isolation methods and identified by spectra analysis (including IR,UV, ¹H-NMR, ¹³C-NMR, DEPT, HMQC, HMBC, NOESY, FAB-MS andHR-FAB-MS) as flowers: n-hentriacontanol (Lc-1), stigmasterol (Lc-2),β-sitosterol(Lc-3), Daucosterol(Lc-4), (-)-epicatechin(Lc-5), (-)-epiafzelechin (Lc-6), Tricin(Lc-7), Ombuin (Lc-8), Acacetin (Lc-9), Kaempferol (Lc-10), Dehydrocorydaline(Lc-11), Palmatine(Lc-12), Berberine (Lc-13), hexadecanoic acid (Lc-14),Protocatechuic acid (Lc-15). n-hentriacontanol (Lc-1), Daucosterol (Lc-4)～Protocatechuic acid (Lc-15) were isolated from this genus for the first time.Cytotoxicity of eight compounds and extract parts were researched with MTTmethods, CHCl₃ extract part showed strong cytotoxicity activity. Petroleum extractpart was analysis by GC-MS.Twelve compounds were isolated from the aerial part of Souliea vaginata(Maxim.) Franch. with various isolation methods and identified by spectra analysisas flowers: Cimigenol (Sc-1), Cimigenol xyloside (Sc-2), 25-O-acetylcimigenolxyloside (Sc-3), Cimiside E (Sc-4), 26(S)-Actein (Sc-5), 26(R)-Actein (Sc-6),26(R)-methoxyactein (Sc-7), cimiaceroside B (Sc-8), Dahurinol (Sc-9), Soulieosides J(Sc-10),β-sitosterol (Sc-11), daucosterol (Sc-12). In the twelve compounds, Sc-10were new compound and Sc-8 were isolated from the genius for the first time.