Qilong Particle Treatment Of Refractory Idiopathic Thrombocytopenic Purpura, Clinical Design And Implementation

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease characterized by low platelets and bleeding,about one thrid of adults with ITP do not respond to standard doses of corticosteroids and aplenectomy and require anther therapy to raise their platelet count, those patients belong to Refractory Idiopathic thrombocytopenia purpura(RITP). The treatment of RITP is barely effective and some patients will relapse within given period.At present, multiple treatments play a more important method in RITP of adult, but response rates are low, or long treatment periods, or high relapse rate,or serious side effects against their use. However, the goal of treatment for patients with ITP is not to cure the RITP, but raise the platelet count high enough levels to prevent bleeding using the least toxic therapy. So the integration of traditional and western medicine is one of promising treatments for RITP.Through the integration of traditional and western medicine, paitents of RITP can maintain a high level of platelet count and improve clinic symptom ,but there are some lacks in traditional Chinese medicine clinic test, such as absencing rules of the treatment based on syndrome differentiation, less objectivity, authernicity and long term security.In the theory of traditional Chinese medicine, blood stasis due to qi deficiency is the essential mechanism of RITP. According to the pathogens, the treatment is supplementing qi, promoting blood circulation for removing blood stasis. we use Qi Long granule as therapy medicine, set a randomized controlled trials (RCTs) to evaluate clinic curative effect of RITP,which is the first time we do this job in traditional Chinese medicine of RITP. So this study is authorized self-determination innovated study in traditional Chinese medicine in 2005 by the fund of medicine development in Beijing (number: SF-2005-031) .At present, the study is not accomplished, wo met a lot of problems in the clinic test and at the same time we improve ourslves, which make our study more scientific and external, In 2009 we can finish the study and report the clinic curative effect of Qi Long granule for RITP.