Changes Of Immune During Physical Exercise And Psychological Stress And Research Of Their Mechanism

Some of the early research that was critical in establishing the relationships between the mind and immune system. The influence of mental status on the course and outcome of a number of diseases, however, was suspected a long time before. Also the links between mental affective disorders and the immune status were repeatedly suggested. The relatively recent field of scienctific inquiry known as psychoneuroimmunology was for the first time comprehensively described in the late 1970s.These and subsequent studies have led to the general acknowledgment that the nervous and immune systems are components of an integrated system of adaptive processes, and that immunoregulatory processes can no longer be studied as the independent activity of an autonomous immune system. Psychoneuroimmunology is the study of the interactions among brain, behavior and immune system processes. The mission of the PsychoNeuroImmunology Research Society (PNIRS) is to delineate these relationships between behavior and immune system, central nervous and immunoregulatory processes and the interactions among mind, neuroendocrine and immune, to try to understand their connections at the molecular level and to use this knowledge to prevent and relieve human pain and suffering. The evidence that the responsiveness of the immune system to stressor duration and characteristics (laboratory stressors, time-limited naturalistic stressors, or chronic stress), emotion status, as well as the influences of psychopathology, personality, interpersonal relationships and behavioral interventions is evidently. The positive mood is beneficial to the immune function, on the other hand, the negative mood induces to the immunosuppresion, even since then to the disease. Members of the research have already made substantial and important contributions toward accomplishing these goals, which including behavioral scientists, psychologists, biological scientists and medical scientists .The studies of the relationships between exercise and immune system promise a better understanding recently. The influence of intensity, duration and frequency of exercise on immune system was differently. Theories about immunosuppression were induced, such as "J" mode, "Open Window " theory, regulation of immunosuppression protein, free radicals regulation, exhaustion of energy sources, regulation of the network of nervous, endocrine and immune, psychological stress and so on.The environment of sports events is complexity. The stressors to the athletes are come from different ways, including from physiological stress and from psychological stress, such as exercise loading, stress of opponents and expectation of coachers, relatives and teammates. Exercise elites in the competition exhibit their integrative abilities of technique, tactics and mentality. But now, the study of the relationship between psychological stress and immune system was independent of that of the relationship between exercise physiological stress and immune system in the laboratory. Up to now, it was no published that analysis rats and athletes completely, observation the influences of long-term exercise stress and psychologicalstress on immune system on the cellar, molecular and gene levels and exploring the characteristics of immune reaction of different types athletes after psychological stress. The studies were clustered according to key themes, including the affects of exercise stress on immune system, psychplogical stress on immune system, and so on. The studies should enrich the theory of psychoneuroimmunoloy and apply to the sports and exercises.The credible model of psychological stress in laboratory should be established to observe the influence of stress on immune system, so two preliminary experiments were designed. One was to probe the method to establish the psychological stess model. 32 male SD rats were assigned randomly to control , empty bottle stress, immobilization stress and electric foot shock condition stress groups. The stress experiments were carried on 3 weeks, 1 week for rats adaption and 2 weeks f...