| ObjectiveCoronary Heart Disease (CHD) is the narrowing or blockage of the coronary arteries, usually caused by atherosclerosis. Atherosclerosis is the buildup of cholesterol and fatty deposits on the inner walls of the arteries. These plaques can restrict blood flow to the heart muscle, leading to lack of oxygen supply even death of tissue. It is also called Ischemic Heart Disease.CHD in Traditional Chinese Medicine (TCM) terms are "chest paralysis","heart pain","heart pumping","real heart pain". The acupuncture method is easy to use and it is better than western medicine because it contains no drugs and no side effect in treating CHD. The effectiveness of acupuncture has a greater prospect but in combination of Ling Gui Ba Fa to treat CHD is seldom mentioned.This thesis is a RCT clinical study. Through Ling Gui Ba Fa to chose the standard acupoints and symptom related Chinese medicine, compare the blood flow in coronary artery, release CHD chest pain and frequency, improve ECG output, reduce coronary artery inflammation, reduce thrombocytes activation, lower HCY level.Data and MethodAccording to the standard selection,160CHD confirmed patients in Shenzhen TCM Hospital are chosen during1/3/2012to31/12/2012.1. Standard of acceptance:a. Have typical CHD or myocardial infarction symptoms.b. ECG confirmed lack of heart blood flow.c. Age between40to80, ECG confirmed CHD.d. Meet the CHD diagnosis standard according to International Cardiology Congress and WHO.e. Voluntary and signed the agreement of consent.2. Standard of rejection:a. Not meet the diagnosis symptom or in the field of TCM "chest paralysis"b. Severe heart brain vessel patient such as heart failure, heart attack with shock or coma, brain bleeding.c. Combined infection.d. Severe liver and kidney function failure.e. Other severe illness such as tumor, lack of nutrition, mental disorder.f. In pregnancy.g. Not follow the clinical trail or those quitted.Trail Method and ProcedureRandomly divide the160patients into4groups:1. Therapy groupAcupuncture according to Ling Gui Ba Fa to chose the acupoints, plus symptom related acupoints. Once daily,30minutes each time,7days as1cycle. Apply2cycles for a total of14days.2. Control group AAcupuncture according to Ling Gui Ba Fa to chose the acupoints only. Once daily,30minutes each time,7days as1cycle. Apply2cycles for a total of14days.3. Control group BAcupuncture according to symptom related acupoints. Once daily,30minutes each time,7days as1cycle. Apply2cycles for a total of14days.4. Control Group CBlank control, no acupuncture applied.All patients were given the same food and drink from the hospital for the2weeks of trial.Record the result before and after the trial, including the adverse effect and the serum level of hs-CRP and HCY. HCY use enzyme linked immunosorbent assay (ELISA), hs-CRP use solid phase chemiluminescence immunization, statistical use SPSS15.0for windows and X2test.Result1. Clinical Result ComparisonBefore and after treatment, the clinical symptoms, body conditions, ECG and blood fats are compared. X2test showed that therapy group T has very significant difference with control group C (P<0.001).Therapy group T has significant difference with control group A and control group B (P<0.05).Control group A and control group B have significant difference with control group C (P<0.05).Control group A has no significant difference with control group B (P>0.05). 2. TCM Clinical Result ComparisonAfter the treatment, results showed that therapy group T has very significant difference with control group C (P<0.001).Therapy group T has significant difference with control group A and control group B (P<0.05).Control group A and control group B have significant difference with control group C (P<0.05).Control group A has no significant difference with control group B (P>0.05).3. Angina Pectoris Condition Comparisona. Frequency of angina pectorisAfter the treatment, results showed that therapy group T has significant difference with control group A, control group B and control group C (P<0.05).Control group A has significant difference with control group C (P<0.05).Control group B has no significant difference with control group C (P>0.05).Control group A has no significant difference with control group B (P>0.05).b. Duration of angina pectorisAfter the treatment, results showed that therapy group T has significant difference with control group A, control group B and control group C (P<0.05).Control group A has no significant difference with control group B (P>0.05).Control group A and control group B have significant difference with control group C (P<0.05).4. Heart Function ComparisonAfter the treatment, results showed that therapy group T has significant difference with control group A, control group B and control group C (P<0.05).Control group A and control group B have significant difference with control group C (P<0.05).Control group A has no significant difference with control group B (P>0.05).5. hs-CRP ComparisonAfter the treatment, results showed that therapy group T has significant difference with control group A, control group B and control group C (P<0.05).Control group A and control group B have no significant difference with control group C (P>0.05).Control group A has no significant difference with control group B (P>0.05).6. HCY ComparisonAfter the treatment, results showed that therapy group T has significant difference with control group A, control group B and control group C (P<0.05).Control group A and control group B have significant difference with control group C (P<0.05).Control group A has no significant difference with control group B (P>0.05).ConclusionThrough the160cases clinical study of coronary heart disease with angina cordis, acupuncture according to Ling Gui Ba Fa to chose the acupoints plus symptom related acupoints has better result than the others.The results are reflected by:lessen the angina degree and frequency, improve blood flow as shown in ECG, inhibit inflammation in coronary artery, inhibit platelet activation, lower HCY level. Acupuncture according to Ling Gui Ba Fa plus symptom related acupoints is better than only using Ling Gui Ba Fa because more acupoints can be used. The typical examples are Tan Zhong Xue and Xin Shu Xue. This maybe the good result in lessen the angina degree and frequency, improve blood flow as shown in ECG, inhibit inflammation in coronary artery, inhibit platelet activation, lower HCY level symptom.DiscussionThe mechanism of Ling Gui Ba Fa on coronary heart disease (CHD). CHD is the narrowing or blockage of the coronary arteries, usually caused by atherosclerosis. Atherosclerosis is the buildup of cholesterol and fatty deposits on the inner walls of the arteries. These plaques can restrict blood flow to the heart muscle, leading to lack of oxygen supply even death of tissue. It is also called Ischemic Heart Disease. CHD reflects lack of blood flow in coronary artery. This lack of blood or oxygen leads to a series of clinical symptoms.CHD in Traditional Chinese Medicine (TCM) terms are "chest paralysis" The cause of this is the body weakness, lack of energy inside the body, low circulation, poor temperature regulation, accumulation of body waste. The symptom can be severe but the root cause is body weakness. This is why CHD is more on the elderly or women after menopause. At that age, the kidney function lowered. The power from kidney to heart becomes less. This leads to a series of heart problem. So the main factor of CHD is the kidney and heart.Acupuncture according to Ling Gui Ba Fa plus symptom related acupoints can deal with this main factor. Improving kidney and heart can cure the coronary heart disease with angina cordis and the accompanying symptoms.A. Basic theoryLing Gui Ba Fa is a timing method to choose acupuncture point in the human body to cure a definite diseases or symptoms. It fits with the meridians system and the function between them. The8acupoints that come across the meridian with main function are Gong Sun, Nei Guan, Zu Lin Qi, Wai Guan, Lie Que, Zhao Hai, Hou Xi, Shen Mai. The origin of this system is very ancient."Nan Jing" mentioned:meridian is a channel or river, the acupoint is like a lake. So the come across function of the8acupoints can regulate the circulation within the body, like a lake regulates the flow in the river. But the flow is time depended. This is just fit to the timing method of Ling Gui Ba Fa. The timing is similar to the human biological clock. The "close" or "open" of the acupoint reflects the flow volume and can be detected by conduct ivy meter. In the stage of "open", blood flow increase. In the stage of "close", blood flow decrease. By method of benefiting in suitable acupoint in "open" stage, the weakness can be lessened.In this clinical trial, the result of the therapy group is significantly better the control group A, B, and C. This reflects the characteristic of the8acupoint and the Ling Gui Ba Fa has a very important function in the acupuncture treatment.B. Characteristics of acupoint combinationDou Han Qing "Zhen Jing Zhi Nan" said:Gong Sun…can use with Nei Guan; Zu Lin Qi…with Wai Guan; Hou Xi…with Shen Mai; Zhao Hai…with Lie Que. This explains the combination and function between the pairing acupoints. The timing is the human to communicate with the nature. Ling Gui Ba Fa fits this point of view and can effectively treat the CHD and the accompanying symptoms. |
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