Research On The Optimization Methods Of Logistics System In Pharmaceutical Circulation Enterprise

The task of logistics of pharmaceutical industry is to secure adequate drug supply of hospitals, community health centers, medicine retail stores and grassroots health institutions. The pharmaceutical logistics is a major livelihood issues for that it may have tremendous consequences for hundreds of millions of people’s health. Pharmaceutical logistics planning is very difficult for the complex relationship of the medical rationing level, outlets, and constraints, rationing system structures. In recent years, the suggestion of relevant medical management departments is to establish and improve the drug supply security system, establish national essential drug system, rectify and standardize the order of production and circulation, and develop modern medical logistics. Without doubt, the main task of pharmaceutical circulation enterprise is to reduce the cost of medicine circulation, improve the efficiency of pharmaceutical supply chain, and improve logistics efficiency of the medicine circulation enterprise. It is significant to discuss the problem about management and optimization of the medicine circulation enterprise logistics system.This dissertation mainly puts important on these aspects contents below of management and optimization of the pharmaceutical circulation enterprise logistics system, i.e. Regional drug demand forecasting and pharmaceutical circulation enterprise logistics demand analysis, site selection and layout of drug distribution center, medical equipment selection, drug storage and ordering management, drug distribution optimization and pharmaceutical logistics supplier selection. The main content of this dissertation is as follows:(1) According to the analysis of the causes and characteristics of fuzzy drug demand, fuzzy mathematics method is used to discribe drug demand, and the fuzzy cut set method is used to determine drug fuzzy demand. The computational results show that the proposed fuzzy cut set method is effective and reasonable compared with the average expectation method and the classic representation method. This dissertation sets up the Markov forecast model and the moving average forecasting model based on influencing factors. Some cases are analyzed and calculated using WinQSB. The results show that the proposed model is effective and credible.(2) This dissertation designs the methods and procedures for selection of pharmaceutical distribution center location, and sets up the P-median location model based on the material flow rate. The from-to diagramming method and the comprehensive evaluation method are used to analyze the logistics relationship, the non-logistics relationship, and the proportion method is used to analyse comprehensive relationship between operating unit. The linear table method and the process judging method are used to optimize the jigsaw puzzle without area and layout of the medicine distribution center operations unit.(3) The data drug inbound and outbound operations is analyzed by EIQ method to get the data numerical characteristics and rules of drug quantity, drug types number, drug inbound and outbound times, drug inbound and outbound quantity. The statistical analysis result is used to reasonably choose medical handling equipment, and design the way of drug storage. This dissertation designs not allowing drug shortage Economic Order Quantity model, allowing drug shortage Economic Order Quantity model, the order model with discrete random drug demand, the order model with continuous random drug demand to determine inventory order strategies.(4) For short-range drug delivery problem, this dissertation sets up multiple loading site-vehicle Poisson arrival distribution-negative exponential service hours-vehicle queuing model, drug delivery VRP model with time window, and two stages open dynamic demand for drug delivery VRP model, designs an ant colony algorithm to solve the VRP model, uses Matlab to code, and carries simulation experiment by simulated data. The results show the effectiveness of the proposed model and ant colony algorithm. A multi-objective model for drug pricing with risk is set, which includes pharmaceutical factories, distribution centers and drugstores with uncertain demands. The manufacturer decision-making and optimal conditions, distribution center decision-making and optimal conditions and drugstore decision-making and optimal conditions are analyzed.This dissertation can provide scientific and reliable theoretical support and guidance method of logistics management and optimization for medicine circulation enterprise, these proposed approaches can effectively reduce drug logistics cost, improve the efficiency of pharmaceutical circulation, and meet the people’s growing health needs.