Study On The Synthesis Of Compounds Containing Saturated Pentaheterocycles And Their Biological Activity

Drought and salt-alkali are crucial factors which hinder the development of agriculture. Through the research on the mechanism of plant stress, it was found that the chemical modulating method was highly effective and practical in resolving the drought and salt-alkali problem of soil. It is important to study and develop the plant stress chemical pharmaceutics, which can better the conditions of soil and improve its effective utilization.Chenghou Lou, a famous plant physiologist, pointed that "The chemical modulating technology of plant is the emergent novelty of agriculture in this mid-century, which is another breakthrough after the fertilizer." This technology regulates the growth process of the individual by spraying a few chemicals over plant or soil. The technology develops the pesticide, which take the first place in variety and quantity in the past twenty years and become a new point of growth in the biochemistry.In order to find the new plant growth regulators, this thesis selected the commercial plant growth regulator RAD as the template. We designed the new compounds by introducing the heteroatom and substituting group into the saturated pentaheterocycles. After collecting a lot of references and combining with the previous research which was based on the project of The National key technologies R&D program., an optimized synthesis route was determined, which had some advantages, for example, easy to synthesize, an acquisitive materials, high yield, and simplicity of operation. Finally we had succeed in synthesizing the target compounds.In this thesis, two series of twenty four compounds were designed and synthesized, as shown in below:These compounds have been confirmed by the spectra of ~1H NMR, IR, and some of them were analyzed by liquid chromatography, and they were also carried out the bioassay...