The Synthetic Technology And Qualitative Study Of IDP0412

One third time in our life is spent to sleep. Sleep is the necessary process in life, is the importance factor of economy recover, conformity, and consolidate memory, is the necessary factor to health. Insomnia is the hackneyed symptom in clinic, incidence of a disease very high.In traditional, deal with insomnia involve the cure and delay of etiology, improve the quality of sleep and take medicine of hypnotic. By explore, cure insomnia from barbital hypnotic and the other CNS inhibitor, hydration chloraldehyde develop to benzodiazepine, for example antipsychotic and so on, and today is non-benzodiazepine. IDP0412 is a new-style of hypnotic, is the best of hypnotic, have preferable applied value.The process of chemical synthesis is the base of search of new drug, we can test the reasonability of methods by reading documents, designing synthetic processes, ahead experiment.To screen and change synthetic methods, we can make the best methods of experiment. To appraise and determine synthetic compounds, we can know its qualitative standard. The qualitative analysis, including character, differentiation, Concentration determination, impurity identification and stability test and so on.There are mainly synthetic technology and qualitative study in this paperThe results of experiment were:1) Synthetic technology: We have decided the ideal synthetic approachs by reading documents, designing synthetic processes,ahead experiment.Its chemical was confirmed as IDP0412 by m.p., element analysis, UV, NMR, MS. IDP0412 is buff spiculate solid, and its concentration is over 99.0% on the base of HPLC.2) Concentration determination: High Perform Liquid Chromatograph(HPLC) was performed in concentration determination. Instrument was waters 2695-2996...