The Synthesis Of Coenzyme Q0

Coenzyme Q10 is well known of its wild use in biology, pharmaceutical, cosmetic. Yet coenzyme Q0 (2,3-dimethoxy-5-methyl-1,4-p-benzoquin-one)is a vital intermediate of coenzyme Q10. In this paper, coenzyme Q0 will get from 3,4,5-Trimethoxybenzaldehyde, after two steps reaction, microwave reduction and peroxide hydrogen, oxidation. This routine is characteristic of commercially available material, moderate reaction conditions.The first step, 3,4,5-Trimethoxybenzaldehyde is reduced to 3,4,5-trimethoxyto-lutene, by microwave reduction, is relatively innovative from technical point. But in fact, it is hard to control this experiment condition. Also the field is low. The oxidation of 3,4,5-trimethoxytolut-ene to coenzyme Q0 is optimized through orthogonal experiment and the synthetic conditions are: . the yield is 65%. Coenzyme Q0 is purified by recrystallization instead of column chromatography which documents present. And the product purity has got 99%. Then we give the possible mechanism taking advantage of experiment design and theory deduction.At the last of this paper, we present that catalysis and mechanism study should be the direction of study and will have new achievements.