One-Pot Reaction Of 3,3-Dimethyl-1-(1,2,4-Triazole-1-YL)-2-Butanone With Secondary Amines And Aldehydes

The feasibility of one-pot three-component reaction of 3, 3- dimethyl-1-(1, 2, 4-triazole -1-yl)-2-butanone was studied and the best reaction conditions, including cayalists, solvent and tempreture were considered. A series of new compounds were synthesized under the best condition which was obtained by the previous works. The structures of these compounds were confirmed by IR, 1H NMR, and theirs melting points were determined. In order to study the relationship between structure and effect of these compounds, the antimicrobial activity to pathogens and bacteria were considered. The main results are as follows:The Mannich type reaction of 3, 3- dimethyl-1-(1, 2,4-triazole-1-yl)-2-butanone, secondary amines and aldehydes reacted in aqueous media is feasible, and its best condition was 35℃in water .Under this condition, 13 conpounds including 6 new compounds were synthesized using 3, 3- dimethyl-1-(1, 2,4-triazole-1-yl)-2-butanone, secondary amines and aldehydes, and their structures were determined by IR and 1H NMR.The results inhibiting pathogenic fungi showed that the inhibitory rate of compounds c, e to Fusarium solani a were66.67%和78.33% at the concentration of 100mg/L; that of f to Fusarium graminearum was 69.23%; c, to Fusarium Cotton-wilt was78.33%. Compound f showed a promoting functions to Fusariumgraminearum.