Studies On The Preparation Technology And Quality Of Dauricine Capsules

Rhizoma Menispermi, the Rhizoma of Menispermum dauricum DC is a kind of Traditional Chinese Medicine in common use and Rhizoma Menispermi tablet, the substance extracted from it is clinically used in treating faucitis. Presently, It is found that the Dauricine have eminent curative effect on diseases of hypertension as well as cardiac arrhythmia . For this reason to develop capsules of Dauricine has significant practical importance.The research is a study on extraction, separation , purification, preparation technology and quality control of capsules of Dauricine by modern techniques, according to the technical requirement in the researches on Traditional Chinese Medicine, the criterion of new Traditional Chinese Medicines in the management of leechdom enrollment .First of all with whole alkaloid of hydroxybenzene as the standard substance , method of Acid-dissolve and alkali-precipitate extraction and preparation are applied on the three different resources of Rhizoma Menispermi, it is found that contest of whole alkaloid of hydroxybenzene of the source drug lie in between percent 73.63 and percent 80.72. Secondly, with extraction method to part Dauricine from whole alkaloid of hydroxybenzene for the first time. Through High performance liquid chromatography the average content of Dauricine is percent 93.22. According to Chinese pharmacopoeia, the technical requirement in the researches on Traditional Chinese Medicine, do research on quality control of capsules of Dauricine, through High performance liquid chromatography, it is found that contest of capsules of Dauricine lie in between percent 91.61 and percent 95.24.The study is on the techniques of extraction, separation , purification , preparation technology and quality control of gelatin capsule of Dauricine, which establishes an important base for the preparation of new Traditional Chinese Medicines.