Study On The Synthesis, Biological Activities Of Novel Substituted Acetophenone With Triazole Derivatives

In this thesis, we have reviewed the recent advances in the studies on thesynthesis, action mechanism and biological activities of triazoles and benzotriazoles,the active group of benzotriazole were inducted into the target compounds accordingto the concept of bioisosterism. twenty-five novel benzotriazole compounds in fourtypes of structure were designed and synthesized. They are summarized as follows:The structures of the novel benzotriazole compounds that were designed andsynthesized in four types were confirmed by means of 1HNMR, IR, EA and X-raysingle-crystal diffraction method determination. The antimicrobial activities weretested too. The contents and the primary contributions of the research are summarizedas follows:1. Twenty-five new compounds containing benzotriazole group were designedand synthesized. Their structures were confirmed with IR, MS, 1H NMR, EAand X-ray single-crystal diffraction method determination.2. Better synthesize method of desirable yield was studied. 3. Antimicrobial activities of new compounds were tested in MTT method andall the compounds were found to show some antimicrobial activities.