Studies On The Synthesis Of Thia/Oxadiazole And Triazole Compounds

With the development of drugs, many chemical workers were interested in thia/oxadiazole and triazole which were indentified as anti-cancer, anti-convulsant, anti-mycobacterial, anti-hypertension, anti-inflammatory, herbicidal and growth hormone biological compounds.In the same time, many chemical workers were interested in the latest research which approved that microwave as a novel heating mode had many merits with excellent yield, short time, simple operation, less secondary reaction and easily separated and purified. In order to realize combination of multiform active ingredients, a series of novel compounds of 1,3,4-thia/oxadiazole and 1,2,4-triazole were designed and synthesised. It extended the research field of such compounds and provided abundant leading compounds for later selecting work of biological compounds and materials.The major accomplishments of this treatiseThe progress in application and synthesis of 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazole, the application of microwave in organic synthesis were systematic exposition.1 A series of unreported diacyl thioureas containing 1,2,3-triazoley have been synthesized by means of microwave irradiation method. After comparison, it was found that the process under microwave irradiation had many merits with excellent yield, short time, simple operation, less secondary reaction and easily separated and purified.2 A series of unreported N-(5-p-chloro-phenoxymethyl-1,3,4-thiadiaol-2-yl)-S-(4-phenyl -5-phenoxymethyl-1,2,4-triazole-3-yl) mercapto acetamide have been synthesized. Its intermediate 4k and 4i crystal structure were determined by the X-ray diffraction.3 A series of unreported bis-1,3,4-oxadiazoles have been synthesized, the UV absorption properties were also studied.