Clinical Study On Treatment Of Knee Osteoarthritis With Deficiency Of Liver And Kidney By

Objective:Observe XIBITONG fang early treatment of liver and kidney deficiency type of knee osteoarthritis clinical efficacy and safety, in order to make clear the legislation on the contact treatment characteristics and advantages of the formulas, and the legislation provide reliable evidence-based clinical popularization and application of the formulas basis and the foundation of further study.Methods:This study intends to use prospective, randomized, controlled clinical trial method, in wangjing hospital of traditional Chinese medicine academy of sciences joint of China from the clinic early liver and kidney deficiency type of 60 patients with knee osteoarthritis, each 30 cases were randomly divided into trial group and control group, experimental group using XIBITONG fang, ts composition,Chinese Foxglove 15g,poriacocos 15g,rhizoma alismatis 9g,pulp of dogwood fruit 12g,roasted Rhizoma AtractylodisMacrocephalae 9g, radix clematidis 9g, homalomena occulta 9g, medicinal cyathula root 9g,rhizoma corydalisl9g and liquorice 6g. Two groups of test results for three weeks, for a period of treatment, two groups during treatment were instructed to quadriceps exercises. Respectively before treatment, treatment 3 weeks (end of the course) for VAS pain and WOMAC score, TCM syndrome score, floating patellar test as observation indexes, such as follow-up and in January after the treatment, in order to make clear the knee bi tong rang used to treat the early liver and kidney deficiency type of knee osteoarthritis clinical efficacy and safety.All the collected test data with SPSS 19.0 software for statistical analysis.Results:1.Be fore and after treatment compared with patients after treatment Rating:According to the results of statistical data analysis, experimental group VAS pain score before treatment was (6.30±0.12) points, WOMAC score was (99.27±1.00), the test group after treatment VAS pain score (2.87±0.94)points,WOMAC score for score(85.43 ±0.60); control group, VAS pain score before treatment was (6.23±0.94)points, WOMAC score was (96.93±1.07);the control group after treatment VAS pain score (3.03 ±1.07) points, WOMAC score was(85.43±0.60).When the patients were followed up for 1 month for VAS pain score (2.57±0.64), (79.43±0.72) for WOMAC score score, while the control group were followed up for 1 month for VAS pain score (2.87±0.71),(81.31± 0.74) for WOMAC score score.Between the two groups before treatment VAS and WOMAC pain scores were statistically analyzed, no significant differences were comparable; both groups after treatment compared with before treatment, showed significant improvement, with a very significant difference (P<0.01), with a statistical significance; between the two groups with each other, in terms of improvement in VAS pain scores, the two groups had no significant difference (P> 0.5), but in terms of improvement in WOMAC score, the two groups have very significant difference (P<0.01), that is, the test group significantly better than the control group.In the two groups were followed up for 1 month VAS pain score and WOMAC score than before treatment, at the end of 3 weeks treatment were improved.2.Two groups of TCM syndromes compare observations:Experimental group of 30 cases, the total effective rate was 96.67%, of which 18 cases (60%), effective 11 cases (36.66%),1 patient (3.33%); 30 cases in the control group, the total effective rate was 90.00%, which 10 cases (33.33%), effective in 17 cases (56.67%),3 cases (10.00%). After statistical analysis, there are always two groups there was a significant difference (P<0.05) efficiency, indicating improving TCM syndrome, the experimental group than the control group.3.Floating patella test results before and after treatment compared to patients:Before treatment, the experimental group floating patella test positive rate 26.67%, ie, floating patella test positive in 8 cases, negative in 22 cases, the treatment group after floating patella test positive rate of 10%, that is floating patella test was positive in three cases, negative 27 cases; before treatment, the control group floating patella test positive rate was 30%, which is floating patella test was positive in 10 cases,20 cases negative, in the control group floating patella test positive rate was 13.33%, that is floating patella test was positive in 4 cases,26 cases negative. The statistical analysis between the two groups before treatment, floating patella test positive cases through statistical analysis, no significant differences were comparable; both groups after treatment compared with before treatment, a significant reduction in the rate of floating patella test positive, significant difference (P<0.05), with statistical significance; to each other between the two groups, no significant difference (P> 0.05), no statistically significant.Conclusion:Experimental and control groups in the liver and kidney deficiency type of knee osteoarthritis significantly effect of early treatment, in terms of improving joint pain, no experimental group and control group significant difference; improving WOMAC score and TCM syndrome score, the test group significantly better than the control group; floating patella test positive rate before and after treatment reduced, but also that its joint swelling and effusion occurred unique inhibition. On safety evaluation, patients in the control group only a mild gastrointestinal reactions, after remaining cases no special medication adverse reactions, drug side effects consistent with the case, suggesting that the legislative prescriptions secure.