Effects Of Sanguinarine On Growth Performance, Nutrient Digestibility And Blood Biochemical Indexes Of Weaned Piglets

Two experiments were conducted to investigate the effectiveness of sanguinarine (SA) and its feasibility of replace of antibiotics in weaned piglet Production. The appropriate addition level of SA in weaned piglets was determinate in experimentⅠ. Furthermore, to compare the effect of SA or chlortetracycline supplementation on growth performance, diarrhea, nutrient digestibility, blood biochemical and immune indexes of weaned piglets in experimentⅡ.ExperimentⅠThe objective of this study was to evaluate the effects of SA on growth performance and diarrhea of weaned piglets. One hundred and sixty Landrace×Yorkshire castrated piglets weaned at 28±2 day were divided into 4 treatments with 5 replicates each treatment and 8 piglets per replicate (pens) randomly. Piglets were fed a maize-soybean meal diet containing either no additive (control group),60 mg/kg chlortetracycline,0.5 mg/kg SA or 1.0 mg/kg SA for 30 days. The results showed that: the ADG of piglets fed with 0.5 mg/kg SA or 1.0 mg/kg SA were higher 10.42%(P<0.05) and 10.81%(P<0.05) than that of control group respectively. But compared with control group, the F/G were both lower 5.00%(P<0.05), and diarrhea rate were lower 65.44% (P<0.05) and 69.12%(P<0.05) respectively. However, there was no significantly difference among three experiment groups with dietary supplement of 1.0 mg/kg chlortetracycline,0.5 mg/kg SA and 1.0 mg/kg SA (P>0.05). And two addition level of SA both promoted the economic benefit of weaned piglests.The result suggested that the effect of dietary of 0.5 mg/kg SA on growth performance in weaned piglets was equal to 60 mg/kg chlortetracycline.Experiment II To compare the effect of SA or chlortetracycline supplementation on growth performance, diarrhea, nutrient digestibility, blood biochemical and immune indexes of weaned piglets, One hundred and twenty Landrace×Yorkshire castrated piglets weaned at 28±2 day were randomly assigned to 3 treatments with 5 replicates each treatment and 8 piglets per replicate (pens) randomly. Piglets were fed a maize-soybean meal diet containing either no additive (control group),60 mg/kg chlortetracycline or 0.5 mg/kg SA for 30 days. The results showed that:①Compared with control group, ADFI and ADG of piglets fed with dietary 0.5 mg/kg SA were increased by 4.84%(P>0.05) and 10.49%(P<0.05) respectively, but F/G and diarrhea rate were reduced 5.52%(P<0.05) and 40.42%(P<0.05), and these items closed to those in group 60 mg/kg chlortetracycline.②Supplementation of 0.5 mg/kg SA in weaned piglets diets significantly improved GLU concentration in serum (P<0.05), but did not affect ALP, ALT, AST, LDH and BUN level in serum.③Supplementation of 0.5 mg/kg SA in weaned piglets diets significantly improved TP, IgG and IgM content in serum (P<0.05), but did not affect ALB and GLOB concentration in serum.④Compared with control group, CP digestibility of piglets fed with dietary 0.5 mg/kg SA were increased significantly (P<0.05), while DM and GE digestibility were little improved (P>0.05). It was concluded that the supplementation of 0.5 mg/kg SA in weaned piglets replace of antibiotics was available.