| In this work, three experiments were conducted to evaluate the effects of metabolic products from Agaricus blazei Murill with submerged fermentation on their functional impacts of immunity and digestion for young animals. The potential of applying the effects on upgrading of immune and digestion was discussed for early weaned piglets.In experiment one, three mycelium polysaccharides and an extracelluar-polysaccharide were extracted from Agaricus blazei Murill through fractioning sequentially with hot water, cold NaOH, and hot NaOH. The four water soluble polysaccharides extracted were investigated for their effects on the proliferation of lymphoid cells of mice with MTT method. Results indicated that, in certain active level, four water-soluble polysaccharides might function alone or cooperate with ConA to activate the proliferation of spleen lymphocyte. In addition, CAWSP (water-soluble polysaccharide extracted by cold alkali) at 0．5-0．25μg·mL-1 concentration revealed a tendency of stimulating the proliferation of spleen lymphocyte that induced by LPS (P>0．05) .In experiment two, mice were fed by the metabolic products of submerged Agaricus blazei Murill as additive for 37%,25% and 13%, respectively. By measuring the organs' index of mice, the intestinal development in terms of alvine absorbing, villous length and lamina propria depth, as well as the antibody level of Bovine serum albumin IgG, the effects of metabolic products from submerged Agaricus blazei Murill on immune function of mice was discussed. Results showed that, comparing with control group, the organ indexes of mice in additive groups were increased (P>0．05) and their intestinal development were improved (P>0．05) ; the average length of intestinal villous of mice fed by middle dose of additive was significantly increased by 22．51% (P<0．05) and the depth of their lamina propria was reduced by 3．98% (P<0．05) . The D-xylose concentration in serum of mice fed by high and low doses was 15% (P<0．05) and 13．78% (P<0．05) higher than it of the control group respectively; moreover, the antibody level of Bovine serum albumin (IgG) from the mice fed by high additive dosage significantly enhanced by 65．11% (P<0．05) .In experiment three, We conducted to determine the effect of on immunity of weaned piglets by appending the products of submerged fermentation of Agaricus blazei Murill on the diet of weaning pig. Thirty six three-way crossbred [Durocx(Landrace×Yorkshire)],21±1-day weaned piglets were divided into 3 groups randomly: basal diet+ antibiotics(CK group),basal diet+ the products of Agaricus blazei Murill(T-A group),basal diet+ the products of Agaricus blazei Murill+ antibiotics(T-AA group).Result displayed that diarrhea rate of weaned piglets in T-AA group was 70% lower than CK group; Agaricus blazei Murill have the effect of improving the performance of weaned piglets and increasing the utilize of feed (P>0．05) ; Agaricus blazei Murill can significant improve total protein (TP)and albumin(ALB) in serum (P<0．05),urea nitrogen(BUN),creatine kinase (CK) (P>0．05) and promote IgG and IgM concentration in serum (P>0．05) ; can significant increased D-xylose concentration (P <0．05) ; the antibody level of Bovine serum albumin in two trial group significant inhanced by 32．92% and 41．61% (P<0．05) respectively.Conclusion: the experiment for the effect of the products of submerged fermentation of Agaricus blazei Murill on young animals showed that, it can improve non specific immunity of young animals; add the products of submerged fermentation of Agaricus blazei Murill in forage can reduce the diarrhea rate of weaned piglets (P<0．05) ,improve the performance of weaned piglets and increase utilize of feed(P>0．05) . the products of submerged fermentation of Agaricus blazei Murill which add in forage can enhance immunological response of organism through upgrading digestive absorption of young animals. Nevertheless, the further study would be required to understand its mechanism.
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