Stuide On Correlation Factors Diversity In The Process Of Curing The Cow Endometritis With Lipoplysacchatide

Cow endometritis is one of cow common illnesses, which frequently pose enormous economyexpenses cow cultivation. Once the dairy cows contract this disease, their conception rate andusage would be depressed, and it's much more acutely that this disease would cause the dairycows infertile and lose their use value. So a great of research worker actively search forefficacious treated method which would be cure the cow endometritis. For the past few years,overseas experts reported that intrauterine filling immunoregulant such as lipopolysaccharidewould to arouse intrauterine immunity, and greatly increase intrauterine immunity function, whosepurpose is to cure cow acute or chronic endometrits.Because intrauterine pathological information is more difficult to be got, such as theintrauterine content and endometrial constitution is difficult to got, the immune metergasis of cowsis difficult to be pursuited and investigated after administer. On account of above-mentionedcircumstance, the study contains to make use of intrauterine infusing LPS to cute cow endometritis,and determine immunizing correlated indexes of peripheral blood: the levels of IL-2, IL-6, IL-8,TNF-α, the levels of T-AOC, SOD, GSH-PX, and free radicle NO, free radical oxidative productMDA to mediately to reflect the immune metergasis in the management process. According to thetreated circumstance after intrauterine filling LPS, we researched how the immunomodulator effectthe uterine and the dependability between intrauterine immunity function and eneral immunity. Itwill to provide a part of information, directions and reference for the new treatment which is theimmunomodulator therapeuticsThe experiment was indicated that curative effect of intrauterine filling LPS for the cowendometritis was conspicuous. In the process of treatment, the contents of cytokine IL-2, IL-6,IL-8increased, the max amplitude time was from 24 to 48 hours after treatment. But the contents ofcytokine TNF-αappeared the tendency which was decreasing first then increasing. It was to explainthat the organism immunologic system had a biggish diversity, and the LPS activated the immunological cells.At the same time, the enzyme activity of the antioxidase and the T-AOC was attenuated, thecontents of the correlated inflammatory factor MDA was abidingly decreased, and the contents ofNO was greatly increased in 48 hours ,than recovered the quondam level. It was indicated that theorganism mobilized a devil of antioxidative factors to discard endosomatic profuse oxygen freeradicals for the purpose of abscising inflammation.