| O.glabra is one of Oxytropis DC.,which is the main locoweeds respoinsible for livestock poisoning rangelands, distributed in the northwest of China. O.glabra causes large economic casuaty of livestock farming. Considering the grassland ecosystem angle, O.glabra has heavy distribution and prosperous root system, besides strong antireversion force and much of Ca,P and protein closeing to lucerne. O.glabra is the important ingredient of grassland ecological community. So we must consider not only the utilization of livestock farming but also ecosystem function of O.glabra, carrying out comprehensive utilization of O.glabra. This research carrys out the detoxication effect of Jidujing, focusing on elements of toxication and detoxication, hoping to develop new way of prevention and cure O.glabra toxication. Cruding alkaloid of O.glabra, we had the acute toxicity test in alkaloid of O.glabra;Evaluated the safety of"Jidujing"; Construated the model of toxication rats feeded O.glabra, and examined their indexes of organ quots, availability of food, the hematology and blood zymologic indexes and had a serise of pathology observation. On the ground of Construated the model of toxication rats feeded O.glabra , we observed the research of prophylactic effect of Jidujing. We tested the Nutrition Contents of Xinjiang O.glabra . The research. gains a series of results:1. The acute toxicity research of Xinjiang O.glabra, which shows the LD50 of the mice feeded of O.glabra. Through extracting the alkaloid of O.glabra, the alkaloid of O.glabra was injected into abdominal cavity, and computed the LD50 of the mice injected the alkaloid of O.glabra. The result shows the LD50 of the mice feeded of O.glabra is 48.9~68.9 g/kg weight.2. The security of Jidujing was evaluated. Through the acute toxicity research of Jidujing, the result shows the LD50 of mice is more 10 times than Ovis aries. On the basis of safety evaluation of drug, it belongs to more safety drug. Generally the acute toxicity can not be caused; According to the clinical symptom, the dose of food and drink of mice has no change , with increasing the dose of Jidujing.3. Construated the model of toxication rats feeded O.glabra and observed the symptom of rats; calculated the organ quot of liver,kidney,spleen and availability of food; detected the hematology and blood zymologic indexes and had a serise of pathology observation. The result shows O.glabra can cause toxication,which take on confused nervous function, descent weight, turgescence of liver,kidney,depauperation of testis and spleen; the liver,kidney,spleen of are full of hyperemia and hemorrhage in part and lymphocytes are soakage,besides basilar membrane of kidney are desquamated; MCH,WBC,MCV,MCHC are smaller than controlled group, which shows there are different anaemia of rats fed O.glabra. AST,ALP and Creatinine are higher than controlled group, which shows that livers,hearts,kindeys are injured. AST,ALP can show the pathological changes of liver than T Bil.4 The research of prophylactic effect of Jidujing shows that Jidujing can put off the toxication time at least 5 days; that the liver,kidney,spleen of safeguardde groups is better than toxication groups, besides the food availability has been improved in some extent; that the liver,kidney,spleen of safeguarded groups are full of hyperemia and hemorrhage in part; that the MCH,WBC,MCV,MCHC of safeguardde groups are higher than toxication groups; that AST,ALP,Creatinine are lower than toxication groups. All that show Jidujing can protect the rats in some extent.5.The Analyse of Nutrition Contents of Xinjiang O.glabra Through the analyse of nutrition contents, we obtained the follow results: crude protein is 12.48±0.20 %, crude fibre is 25.06±1.48 %, raw fat is 2.25±0.14 %,calcium is 1.44±0.06 %, phosphorus is 0.033±0.00 %, elenium is 0.0657±0.0127 mg/kg. On the aboved results, we knowed that the security of Jidujing was high, and Jidujing could partly protect the rats poisoned by Xinjiang O.glabra. Besides , The nutritive value of Xinjiang O.glabra was high and was in low of selenium level, which showed the selenium level of Xinjiang O.glabra could not lead to poison of Xinjiang O.glabra.of domestic animals.
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