EXPRESSION OF P16 PROTEIN AND PCNA IN TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER AND THEIR IMPLICATIONS

Objective The aim of this study was to assay the expression of p16 protein and PCNA in transitional cell carcinoma of bladder (TCC) and their relationship to TCC pathological grades, clinical stages and prognosis. Materials and methods There were 59 cases of TCC, and the mean age was 50.3 years. According to the indications of S-P immunohistochemical assay, p16 protein and PCNA were detected in 59 cases of human transitional cell carcinoma of bladder. Results The positive rates ofpl6 protein in G1.. G2.~ G3.. Tis桾1 group and T2桾4 group are 85.35%~ 51.61%~ 9.09%~. 63.41% and 27.78%~ With the increasing of pathological grades and clinical stages, the expression of p16 protein was decreasing (P<0.05). The positive rates of PCNA in G1~ G2~. G3. Tis T1 group and T2 T4 group are 35.29%~ 70.97%~. l00.00%~ 56.10% and 88.89%. The higher pathological grades and clinical stages were, the higher the expression of PCNA was (P<0.05). There were some relationships between p16 and PCNA in TCC specimens. Conclusion To detect p16 protein and PCNA together is an important method in the evaluation of the malignancy and prognosis of TCC.