| The Relationship of Serum Folic Acid Concentration with Helicobacter Pylon Infection and Gastroduodenal Diseases.Master candidate: Sushil Praj apatiSupervisors:Prof: Chen Zheng Nong, I-long Rui Xiang.Asso. Prof:Tang Guo DuDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University.ABSTRACTObjective:To investigate the relation of serum folic acid concentration with Helicobacter pylori(Hp) infection and gastroduodenal diseases.Method:We used Radioimmunoassay to determine serum folic acid levels of 176 patients whose endoscopic and pathologic diagnoses were normal (n=9), chronic gastritis (n=87), gastric ulcer (n~26), duodenal bulbar ulcer (n==3 4), gastric cancer (n20). At the same time Helicobacter pylon was also examined.Results:The results showed that 83 of the 176 patients were infected by Hp(47.16%). There was no statistical difference between Hp positive patients and Hp negative patients(P>0.05). The serum folic acid levels in gastroduodenal diseases were lower than that of normal groups but significantly lower in Gca, CG groups (P<0.0 1 ,P<0.05). Gca serum folic acid level was significantly lower than in benign gastric disease and normal groups but serum folic acid level in Gu was higher than in CG and Gca groups(P<0.05). At the same time serum folic acid levels had no relation with the activity and degree of gastritis (P>0.05). The serum folic acid levels in patients with dysplasia were significantly lower than those without intestinal metaplasia or dysplasia (P<0.05) and there were no statistical difference between dysplasia and Gca groups(P>0 .05).Conclusion:This study indicates that there are no correlation between serum folic acid level and Hp associated gastroduodenal disease. Folic acid may work as a mucosal protecting factor and decreasing its level may play a role in the carcinogenesis of gastric mucosa. The supplement of folic acid in preventing cancer is worth for further research.
|
PDF Full Text Request