A Study On The Relationship Between Gentital Tract Immunity And Clinical Course Of NGU

Non-gonococcal Urethritis (NGU) has been the most common sexually transmitted disease in Europe and United States since 1970s. In recent years, the incidence of NGU has been increasing in China very quickly. NGU is caused by several kind of pathogens except Gonococca. Chlamydia trachomatis (CT) and Ureaplasma urealyticum(UU) are the major pathogens , leading to 50-60% and 20-30% of NGU separately. The clinical symptom of NGU is not serious, but the clinical course is persistent and latent. NGU can cause many complications, such as prostatitis, epidiymitis, salpingitis, pelvic inflammation, infertility, ectopic pregnancy, and so on. Because its harmfulness, more and more attention has been paid on NGU. However, therapy effect of antibiotics is not satisfactory. Especialluy for CT, its clearance is very low in vivo because of its special biological characteristics.For NGU infection, different people have different clinical curses. Some patients can be cured quickly, while others persist for a longtime. This phenomenon shows that different people have different reactivity and resistance to the pathogens. It maybe have some relations with the difference of patients immunologic function. Many studies show that local immunity has some effects on it, especially SIgA and IFN-. But now, most of the studies are based on cell culture and animal models. The studies on the relationship of local immunity of human genital tract with clinical curse of NGU haven't been found.Method: Collect the cervical secretion of the patients and detect the level of SIgA and IFN- in the secretion.Result: The level of SIgA and IFN-is 34.29+15.92mg/l and 97.13+24.00pg/ml in infected group, 47.57+19.61mg/l and 120.7 + 33.78pg/ml in uninfected group, PK0.05 and P2<0.05. The level of SIgA and IFN-fin CT , UU and CT+UU infected groups have no significance difference.Comparing the symptom-group with non-symptom-group, the level of SIgA and IFN-fis 47.00+22.37mg/l and 119.27+ 37.15pg/ml, 33.50+16.25mg/l and 96.45+26.45pg/ml ,P1<0.05 and P2O.05.Conclusion: NGU infection have marked relation with the localimmunity of genital tract . SIgA and IFN- secreted by mucosa of genital is very important to prevent and resist the local infections. With the level of SIgA and IFN-yincreasing , the resistance to infection is enhanced. However, SIgA and IFN- are only one part of local immunity. NGU infection is very complicated and its clinical course is affected by many factors.