The Value Of Serum High-Sensitivity C-Reactive Protein For Predicting The Clinical Severity And Short-Term Prognosis In Patients With Acute Coronary Syndrome

Objective: Recent evidence has demonstrated that c-reactive protein (CRP),a non-specific acute phase reactant, has been found to be an independent cardiovascular risk factor. Measurement of CRP plays an important role in determining vascular risk. This study is to evaluate the value of serum high-sensitivity CRP (hs-CRP) for predicting the clinical severity and short-term prognosis in patients with acute coronary syndrome (ACS).Methods: Serum hs-CRP was measured in 37 healthy subjects, 31 stable old myocardial infarction (OMI) patients, 24 unstable angina pectoris (DAP) and 26 acute myocardial infarction (AMI). ELISA was carried out to detect hs-CRP quantitatively. Serum cardiac troponin I (cTnl),creatine kinase (CPK)and isoenzyme MB (CK-MB)were also measured in UAP and AMI patients. Combined with coronary angiography, the incidence of major cardiac events within hospitalization was assessed. Result: The serum level of hs-CRP in OML UAP and AMI were all significantly higher than that in control, but there was no significant difference between UAP and AMI. Serum hs-CRP was in direct proportion to the number of injured coronary artery in patients with ACS (rs=0.609, P=0.002), when 8.2 mg/L was considered as the cutpoint of hs-CRP, the incidence of major cardiac events within hospitalization was higher in patients with an abnormal hs-CRP than in patients with a normal CRP (46.2% vs 12.5%, P<0.01). For cardiac events, the sensitivity was 80%, negative predictive value was 87.5%, accuracy was 66% by serum hs-CRPlevel.Conclusion: The present study indicates that serum hs-CRP is a riskfactor of coronary artery disease, it can reflect the clinical severity, markunstable atherosclerotic plaque and predict the prognosis of patients withacute coronary syndrome.