The Detection Of The Main Immunnohistochemical Marks Of Breast Carcinoma And The Analysis Of Its Clinical Value

Objective Comparing the value of thin needle core biopsy and thick needle core biopsy to detect three kinds of the main immunohistochemical marks such as the estrogen receptor state (ER) and progesterone receptor state (PR) and proto-oncogene protein cerbB-2 (cerbB-2)to determine whether the needle core biopsy can replace the routine pathyological diagnosis for breast carcinoma , furtherly to direct us making resonable chemotherapical regimens or endocrine therapy or biological regimens, lesting the bias and impossibility of detecting the three marks caused by the complete response or partial response after chemotherapy or endocrine therapy, lesting the blindness of systemic treatment caused by the lack of marks'results.Patients and methods samples were taken from 19 patients with breast carcinoma by three kinds of methods such as thin and thick needle core biopsy and the routine resected biopsy to detect the three main immunohistochemical marks by monocolonal antibody methods, comparing the values of the three methods in the same sample. Chi-square test is administered statistically to analysis the results.Results The result of thick needle core biopsy group is equal to that of routine resected pathyological biopsy: the possitive rate of ER , PR and cerbB-2 is 84. 2%, 84.2% and 36. 8% respectively, the negative rate of ER, PR and cerbB-2 is 15. 8%, 15. 8% and 63. 2irrespectively,the overexpression rate of cerbB-2 is 15. 8%. The results of thin needle core biopsy: the possitive rate of ER,PRand cerbfr2 is 52. 6%, 52. 6% and 5.2% respectively, the negative rate of ER,PR and cerbB-2 is 15. 8%, 5. 2% and 52% respectively, the rate of no tuma samples in the three marks group is 21 % ,31. 6 % , 21% respectively,the rate of no colors of the three marks is 10. 5% , 10. 5% and 0. Comparing the results of ER and PR of the three groups (thin and thick needle core biopsy and routine resected biopsy) , the significant difference was noted statistically (P< 0.05), however, no signifficani difference was noted statistically between the two groups(the thick needle core biopsy and the routine resected biopsy) P>0. 05. Furtherly, comparing the result of the thin needle core biopsy to that of the thick needle core biopsy ,the significant diffirence was noted statistically P0. 05). It shows that the volume of the sample taken by thin needle can correctly detect the ER and PR as good as the other two metheds. Comparing the results of cerbB-2 of the three groups (thin and thick needle core biopsy and routine resected pathological biopsy) , no significant difference was noted statistically (P> 0. 05) , furtherly , comparing the thin needle core biopsy to the thick needle core biopsy , no signifficant diffirence of the results was noted statistically either(P>0. 05). 4 cases have no samples in the thin needle biopsy group, the rate of all is 2l5/o(4/19) , it may ulter the result of thin needle biopsy, the cases are not considered in the group, no signifficant difference was noted statistically either ( P>0. 05). It shows that the volume of the sample taken by the thin needle can also correctly detect cerbB-2 as good as the other two methods. If we control the course of the thin needle core biopsy and the course of detecting the three marks, much more valuable results may be taken from it. Concolusion The thick needle core biopsy can correctly detect ER and PR and cerbB-2 in place of the routine resected pathological biopsy, it can be suitable for the breast carcinoma before newadjuvant chemotherapy or newadjuvant endocrine therapy or biological therapy in order to make a resonnable systemic regimen. The volume of the samples taken by thin deedle core biopsy is big enough to correctly detect the marks...