The Change Of Coagulative, Fibrinolytic Markers And The Clinical Research In Acute Cerebrovascular Diseases

Objective To investigate the characteristic change of the hemostatic and fibrinolytic markers in patients with acute intracerebral hemorrhage (ICH) and lacunar infarct(ICI) and get theory foundation for treatment.Methods A series of hemostatic and fibrinolytic parameters were measured among 37 cases of ICH and 36 cases of ICI by using ELISA or coagulative and flocculent immunoassay.The parameters include t-PA, PAI-1, PC, D-dimer, AT-III, Fib. Meanwhile,thirty-five age-and sex-matched healthy subjects are tested as control group.Results Plasma level of t-PA is elevated significantly in ICH and ICI cases. ( P < 0.001 ) . In ICH cases, the level of PAI-1 is lower and PC is higher in significance (P=0.01, P< 0.001 ) The plasma level of D-dimer in ICH and ICI is elevated, matched as control group. ( P=0.01,P=0.09 ) . The levels of AT-III and Fib in ICH and ICI are lower significantly than those in control cases.Conclusion There are the hemostatic abnormalities in acuteintracerebral hemorrhage. The changeable law of level of t-PA andPAI-1 are significantly different between hemorrhagic and ischemicstroke.Those changeable laws are significantly different between lacunarand ischemic infarct.