| Iodization of salt is generally considered a first-line public health measure for preventing and controlling endemic goiter induced by iodine deficiency. As we have known, iodine deficiency in communities not only causes endemic goiter, but also results in a host of abnormalities collectively known iodine-deficiency disorders (IDD). Although seafood which full of iodine is the popular diet of the local people, people in Zhoushan island was considered a mild iodine deficiency island in the general survey of Zhejiang province in 1993. lodization of table salt, as a public health intervention to eliminate iodine deficiency, was carried out in 1995 in Zhejiang province. Too low concentration of iodine in salt cannot control the incidence of goiter; however, unnecessarily high iodine intakes may occasionally be associated with iodine-induced hyperthyroidism and other side effects such as autoimmune disease of thyroid gland. So it is necessary to evaluate the iodine nutritional status of people in special age, sex, and district, et al in the period of salt iodization.The urinary iodine concentration, the size of the thyroid gland, thyroglobulin of blood and TSH value of neonate et al were often used to evaluate iodine nutritional status of people. And diet investigation and intelligence test were also used in the studies of iodine nutritional status.The aim of this study was to compare the nutritional status of iodine in the iodized salt group and non-iodized salt group to weight the benefits or risks of correcting iodine deficiency through salt iodization, and to give suggestion to the local government.MATERIAL AND METHODSIn Zhoushan islands, Dinghai and Daishan districts were selected as the study areas because of the similarity of socioeconomic status and the difference between using iodized salt and non-iodized salt. Daishan local people use non-iodized salt because there are a lot of peasants who make living on the sea salt and sale it to the neighborhoods, while Dinghai local people use iodized-salt since the iodization of table salt was carried out in 1995 in Zhejiang province. According to the sex and age of residents in Zhoushan islands, 100 gravida, 300 babies, and 50 students for each grade (grade one of primary school to grade three of senior school) and 500 adults above 20 were investigated respectively in Dinghai and Zhoushan districts.The investigation was carried out within the same month. A constructed questionnaire that had been tested in a pilot in the target people was used in this study. The questionnaire consists of two parts: one is the general condition of the subjects and the food-intake frequency questionnaire (FFQ). The size of the thyroid gland of each adult was palpated and was graded according to the criteria of the World Health Organization, the United Nations Children's Fund, and the International Council for Control of Iodine Deficiency Disorders. A urine sample (5ml) was collected from each participant during interview hours, the urine sample were refrigerated at 4 ℃ until they were analyzed for iodine content by means of manual acid digestion and spectrophotometric detection of iodine by eerie ammonium reduction in the Sandell-Kolthoff reaction. In addition, the intelligence test and TSH values of neonate were preceded in the investigation for the student and neonate respectively.Data processing and statistical analysis were carried out using Epiinfo6.04 and SPSS10.0 for Windows. The database was set up using Epiinfo6.04. All the data was input blindly by two persons, and validated by the validate program of Epiinfo6.04, and then corrected according to the questionnaire if they were different. The Mann-Whitney test was used to compare the urinary iodine concentration and dietary iodine intake of the iodized salt group and non-iodized salt group. The Spearman correlation was used to look for the correlation of the urinary iodine concentration and dietary iodine intake. Ordinal regression was used to explore the main factors of urinary iodine concentration, Poisso...
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