Studies On Medicinal Value Of Aconitum Gymnanodrum Maxim In The Northwestern Plateau, Sichuan

There are abundant medicinal plant resources in China.Aconitum L.plant is the considerable genus for medicine of the angiosperm,in which 36 species can be used as drugs. Aconitum gymnanodrum Maxim(AgM) is the only specie of Sub gen. gymnanodrum in Aconitum Z,.,the leave,flowers and roots of which can all be used as drugs.Its waste is pungent and its property is mild.It can treat the pains in the joints,rheumatism etc.Its all grass is poisonous and it is one of poisonous weeds which may imperil the ecological environment of the grasslands.To develop and utilize AgM rationally,we have studied its medicinal value by typical pathological animal models and acute toxicity of its stalk and leave in mice by modified Kaber method.The studies indicate:(l)50 percent water decoctions of stalk and leave of AgM(2g/kg,ip) can markedly inhibit the swelling of the ear caused by dimethylbenzene in mice (p<0.05),whose rate of inhibition is 26.49 percent.They (Sg/kg,ig) can also strikingly decrease the quantity of dyestuff in the abdominal cavity of mice caused by acetic acid(p<0.05),whose rate of decrease is 38.67 percent.(2)50 percent water decoctions of stalk and leave of AgM(2g/kg,ip) can obviously improve the threshold of pain in pain model mice induced by hot plate (55 ) at 60th minute (p<0.05),whose rate of the raise is 55.62 percent.They (10g/kg,ig) can markedly decrease frequencies of twisting reaction induced by aceti acid in mice (p<0.01),whose rate of the decrease is 47.33 percent.(3)A drop of 50 percent water decoctions of stalk and leave of AgM(appropriate 25mg crude drug) has evident cardiotonic effects.Appropriate lOOmg crude drug can make the independent heart inhibitted entirely.(4)Median lethal dose (LD5o) of 50percent water extracts precipitated with alcohol of stalk and leave of AgM is 10.18g/kg,whose 95 percent confidence limits are 8.78~11.80g/kg.The results show that the stalk and leave of AgM has fairly good anti-inflammatory,analgesic and cardiotonic effects,but its safe range is very narraw and it has considerable toxicity.The studies provide scientific basis for synthetical development and utilization and control of AgM,moreover they have important effects on protecting the ecological environment of the grassland and promoting the development of the livestock husbandry in grasslands.