| Object: The Wistar rat model of iodine deficiency was made successfully.Following that, the potassium iodide and potassium iodated were given to the rat model with different groups respectively. Before and after feeding the compounds, the rate of iodine metabolic in rats and the 131I-uptake rateof thyroid gland were examined, the level of T3 and T4 in serum were measured and the variation of antioxidative capability of brain were observed.Methods: 90 Wistar rats were divided into two groups - low iodine group(LI) and normal iodine group (NI). The LI rats were fed with low iodine food and deionized water. Three months later, 20 LI rats were chosen from LI group randomly, and then the volume of urine and content of urinaryiodine in 24 h were measured for each rat. Following that, Na I andNa 103 were injected into rat abdomen for testing 131I-uptake rate. Finally, the rats were killed by bloodletting from femoral artery after 6 hours afterinjection. The thyroid glands were weighted, I-uptake rate examinedand the level of T3 and T4 in serum determined for each rats. All of data of 20 rats were shown that the rat model of iodine deficiency was made successfully.The other deficiency iodine rats in LI group were divided into three groups: (1) LI-LI, fed with deionized water and low iodine food continually; (2) Ll-I, fed with 0.3ug/ml potassium iodide and low iodine food; (3) L1-O, fed with 0.4ug/ml potassium iodated water and low iodine food for another three months. The data including the weight of thyroid gland, 131I-uptakerate of thyroid gland, the level of urinary iodine and TS and T4 in serum, and the content of SOD, GSH-Px and MDA in brain were observed for each rat as well.In the other hand, the NI rats of two groups were fed low iodine food in same time; but One of them was fed the water containing 0.3ug/ml KI andanother were fed the water containing 0.4ug/ml KIO3 for 6 months totally.All items tested were same as that in LI group observed.Results: In this experiment, It was shown that thyroid weight in ratswere increased, the level of T4 in serum decreased and the excretion of urinary iodine were declined in LI group since The rats had been fed low dietary for three months. So it was demonstrated that the deficiency iodine rat had been established well. In the other hand, all of data including the weights of thyroid glands, the level of urinary iodine and serum T4 in LI rats were lower than that in LI-I and LI-O respectively, but they were not significant different between LI-I and LI-O group, and neither in NI and NO group. The activity of SOD in LI-LI group was lower than in LI-I group (P<0.05), but not different significantly compared with other groups (LI-O and NI); the content of GSH-Px in LI-LI was less than that in other three groups (P<0.01), meanwhile, the content of Malondialdehyde (MDA) of brain in LI-LI was higher striking than that in others (P <0.01). In another hand, each of GSH-Px, SOD and MDA was not different between LI-I and LI-O rats (P>0.05) when the rats were fed with low iodine dietary. In first three months; neither were they when each of group was compared with NI rats after giving iodized salt.Cone I us i ons : l.The level of excretion of urinary iodine is varied with the content of iodine in drinking water.2.There was no significant difference between intake- rate of potassium iodine and intake-rate of potassium iodate in thyroid gland for low iodine rats.3.There was no significant difference between uptake - rate of potassium iodine and potassium iodate in thyroid gland for normal iodine rats.4.It is effective for LI rat to treat with a reasonable dosage of potassium iodide or potassium iodate.5.The decreasing of content of GSH-Px and increasing of MDA of brain in low iodine rats suggest that the damage of rat brain may come from oxidizing of free radical.6.There were no variation of antioxidative capability of brain between two group rats which were treated potassium iodine and potassium iodate respectively; and the...
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