Studies On Constituents In The Effective Part Of Datura For Treatment Of Psoriasis

Datura is dry flower of Datura metel L. It belongs to the family of Solanaceae. The drug is warm in nature and pungent in flavour. It has the effects of arresting cough and relieving asthma, relieving spasm and alleviating pain. In the clim'c,the drug is commonly used to treat chronic bronchitis bronchiad asthma and psoriasis.The injection of Datura has been used for the treatment of psoriasis these years and it showed an excellent curative effect. The method has advantages such as high cure rate, low relapse rate and so on.Clinical application of treatment psoriasis was identificated, and gives systemic studies, chemical constituents have been isolated and identified.By ion exchange resin 732(001 x 7) and AB-8 Macropore Adsorbing resin with silicagel column chromatography, ODS column chromatography and polyamide chromatography, six compounds (1-6) have been isolated from the 50% effective fraction of treatment psoriasis, using 1H-NMR, 13C-NMR, DEPT etc., we have indentificated chemical structures of six compounds:Kaempferol, 7-O-α -L-rhamnopyranosyl-Kaempferol, 7-O-→ -D-glucopyranosyl-Kaempferol, 3-O-α -D-glucopyranosyl, 7-O-α -L-rhamnopyranosyl-Kaempferol, 3-O-α-L-rhamnopyranosyl(l → 6)-β -D-glucopyranosyl,7-O-β -D-glucopyranosyl-Kaempferol, β -D-glucopyra nosyl(1→2)-β -D-glucopyranosyl-Phenethyl alcohol. The compounds 4,10 and 14 were isolated from Datura metel L. for the first time.The result of this article not only has important value in theory, but also provides foundation for making effective fraction of Datura metel L. into a new drug.