ResearchEffectsofSalviaYunnanensisC.H.Wright,SalviaPrzerwalskiiMaxim, Salvia Przewalskii Maxim Var Mandarinorum Stib In Hemodynamics During Myocardial Ischemia And The Protective Effects During Acute Myocardial Ischemia And Reperfusion Injury In Rats

Objective: To observe the effects of Salvia yunnanensis C.H.Wright, Salvia przerwalskii Maxim and Salvia przewalsk Maxim var mandarinorum stib in hemodynamic abnormality induced by myocardial ischemia and their protective effects in myocardial ischemia/ reperfusion in rat. Methods: 1.After injecting the drugs though the femoral vein, we have examined LVSP, LVEDP, HR, ±dp/dtmax,t-dp/dtmax, HR, SBP, DBP and MAP in the model of ligating left anterior descending coronary artery (LAD) in rats; 2.We made the model of myocardia ischemia/reperfusion injury in rat by ligating the LAD for 30 minutes and followed reperfusion 60 minutes. The concentration of CK, LDH, SOD, GSH-Px and MDA in plasm were tested. 3.Via the Langendorff heart reperfused model, 5 mintutes after used the drugs, we have made the rat's heart ischemia for 15 minutes and reperfusion for 30 minutes. During the whole process, we exanined the flow of coronary artery, degree of myocardial contraction, heart rate and the concentration of the CK, LDH, SOD, GSH-Px and MDA in perfusion liquid. Results: Salvia yunnanensis C.H. Wright, Salvia przerwalskii Maxim, Salvia przewalskii Maxim var mandarinorum stib can alleviate the depress of LVSP, ±dp/dtmax, t-dp/dtmax and the increase of LVEDP. But the obviously effects on heart rate , SBP, DBP and MAP have not observed.All the treatment groups in doseage of 4g/kg can decrease the concentration of CK, LDH and MDA, and can heighten the concentration of SOD and GSH-Px in plasm after acutemyocardial ischemia/reperfusion. In the model of Langendorff heart perfused, the flow of coronary artery, degree of myocardial contraction, heart rate of the treatment groups are obviously higher compared with the untreatment group. The concentration of the CK, LDH and MDA decreased and that of SOD and MDA rised. Conclusion: Salvia yunnanensis C.H.Wright, Salvia przerwalskii Maxim, Salvia przewalskii Maxim var mandarinorum stib can ameliorate the abnormality of the hemodynamics and have the cardioprotective effects in myocardial ischemia/reperfusion in rat hearts.