Correlation Of The Expression Of Vascular Endothelial Growth Factor,Matrix Metalloproteinases-9 And Proliferating Cell Nuclear Antigen And The Relationship With Biological Behavior Of Gastric Cancer In Gastric Cancer Tissue

The emergence mechanism of the tumour is very complicated, not merely involve many kinds of cancers gene, restrain the change of the cancer gene, and the emergence at the tumour of some cells factor plays a certain role while developing. Though these genes, function ways in the cell of cell's factor are different , function way and function position are different, but the final results will all cause the malignant hyperplasia of the cell. So, the growth of the tumour is not only the growth of the volume of pathological change, the more important thing is that cells hyperplasia activation changes, it is an important means to find out a-bout biological behavior of tumour to study the hyperplasia activation. Tumour cell hyperplasia increase of activation might is it clone more inferior productions of group and help some inferior group of acquisition among them to soak into, shift ability to result in.The proliferating cell nucleus antigen ( PCNA) is that a kind of molecular weight is the acid nucleoprotein of 36kD, gather more coenzyme of enzyme 8 for DNA. PCNA can cycle getting endogenous to organize mark thing as cell, it in close relation with cell hyperplasia cycle to express degree, regarded as one of the indexes of appraising cell's hyperplasia activation. In colon cancer, lung cancer, thyroid gland cancer, stomach cancer at a lot of malignant tumour, PCNA positive person who express express tumour hyperplasia activation of cell , shift latent energy , is it have remarkable dependence with tumour to recur.Growth of tumour is many stage, many step involving multifactor course. In this course, blood capillary forming and tumour are grown and shifted and close-ly related with. Verify tumour cell can secrete some urge blood vessel form material call that tumour blood vessel form factor already now (TAF) , TAF formulation of the blood vessel to the tumour is very important. The vascular endothe-lial growth factor (VEGF) has been shown to be an important regulator of tumour angiogenesis. VEGF is playing an important role in the tumour blood vessel takes shape, leather growth factor and receptor are that the blood vessel produce the key factor in the course in the blood vessel, it is in close relations to grow and attack and shift with the tumour. Entity tumour hyperplasia is it leave blood vessel turn into, blood vessel turn into it is malignant tumour that proliferate, shift essential condition that spread one of rapidly to shift, among them VEGF is playing an important role.The matrix metalloproteinases (MMP) is one kind with Zn2+ a protease family of the auxiliary factor, degrade the host (ECM) outside cells mainly in the body, the degradation, reconstruction, inflammation of the connective tissue react, the tumour spreads and shifts and lacks the blood with meagre oxygen to damage etc. to participate in. Body many kinds of cell can produce MMP, various kinds of tumour cell for instance, become fibre cell, monocyte and macro-phage cell of blood, etc. Endothelial cells of blood vessel can produce MMP too. MMP that endothelial cells produce is significant in blood vessel taking place, forming and regeneration.The matrix metalloproteinases-9 ( MMP-9) is an important member of Mumps family, bottom for basis membrane and main composition of the host outside the cell thing of it--IV Type collagen enzyme, function as skeleton, degrade basis membrane and host albumen hydrolase of composition outside the cell, can promote cancer cell s infiltration to the surrounding tissue , play an important role in the infiltration at the tumour, formulation of transformation and blood vessel. Can secrete to shift the cancer cell that is inclined to or leads other cells to secrete a large amount of MMP-9s by oneself, destroy the integrality of the basis membrane, cause the cancer cell to shift to other position? The great activation depending on the host metal protease happens in the blood vessel, the growth of the tumour new born blood vessel can be suppressed by host metal protease inhibitor . MMP-9 can raise tumour e...