The Clinial Significance Of Lung Resistance-related Protein Gene Expression In Patient With Acute Myeloid Leukemia

Objective: To investigate the relationship between the expression of lung resistance-related protein (LRP)gene and multidrug resistance (MDR)in patients with acute myeloid leukemia(AML). Method: The expression of lung resistance-related protein gene was detected in 62 patients with AML and 10 normal subjects by semi-quantitative reverse transcriptase-polymerase chain reaction(RT-PCR), using β-actin as internal reference. Result: LRP/β-actin≥ 0.0833 was defined as LRP gene expression positive. LRP was positive in 23 of 62(32.3%) patients. The expression of LRP gene was correlated with FAB subtype. Forty three patients received standard induction chemotherapy. Theexpression of LRP mRNA and positive percentage of LRP in relapsed/refractory group were significantly higher than in newly diagnosed group(P<0.05). The complete remission (CR) rate was 69.8% for total study population. The CR rate was 82.3% for patients without LRP expression. But only 42.9% for patients with LRP expression (P<0.01). LRP gene expression was follow-up detected in 10 patients. Survival was longer in patients with LRP" than in patients with LRP+. Conclusion: Overexpression of LRP gene appears to be another clinically relevant drug resistance gene and predicts for poor outcome in AML.