| Objective and Background DataInsulin - like growth factors (IGFs) have been suggested to be involved in the pathogenesis of atherosclerosis and cardiovascular diseases as crucial players in the onset of conditions predisposing to the disease. Low serum concentration of IGFs might be associated with increased risk of ischemic heart disease. But there have been few in vivo studies detailing the relation between dynamic sero-logical changes of insulin - like growth factors and the setting of acute myocardi-al infarction ( AMI). The purpose of this study was to investigate the usefulness of type I and type II insulin - like growth factor (IGF - I , IGF - II ) of a-cute myocardial infarction in conjunction with C - reactive protein, as well as the relation between dynamic changes of IGF - I and IGF - II and the acute phase of AMI.MethodsPatients and groupsIn the Department of Cardiology, the Second Hospital affiliated to China Medical University, 43 patients were enrolled into the current study, Of the 23 patients with AMI ( AMI group for short) , 20 suffered a stable angina pectoris (SAP) ( SAP group for short) , between 2003 and 2004. Another 20 individuals without any cardiovascular problems were as control group.Study ProtocolBlood samples were taken from a peripheral vessel in all enrolled individuals. In addition to the determination of blood glucose, lipoprotein, leukocytes and CPK - MB, patients consented to three laboratory tests: serum IGF - I , IGF - I and CRP. Serum IGF - I , IGF - I and CRP levels in patients withAMI were drawn and measured at six different time periods; at 6, 12, 18, 24, 48 and 72 hours after onset of the disease. And the same test in patients with SAP and control individuals were obtained once at the early morning before breakfast. Serum IGF - I , IGF - II levels were measured by immunoradiomet-ric assy, and CRP was by scatter turbidimetric assy.Statistical analysisSPSS10. 0 for windows was used for statistical analysis. The significance of the associations between IGF - I , IGF - II and CRP was determined using One - Way ANOVA and correlation analysis. Probability values p < 0. 05 were considered statistically significant.ResultsSerum concentration of IGF - I and IGF - II in AMI group was significant higher than those in SAP group and control group ( p <0. 01). Serum IGF - I and IGF - II levels in SAP group were lower than in control group ( p <0. 05). Individuals who develop AMI had higher serum CRP level compared with SAP patients and controls (p <0.05). There was no difference in CRP concentration between SAP and control groups (p >0. 05). The measurement of blood leukocytes failed to indicate statistically significant differences between the AMI and the non - AMI patients ( p > 0.05).Results from serum IGF - I and IGF - II levels for the six time periods showed that the peak of IGF - I concentration was at 24 hours, and that of IGF - n was at 72 hours after onset in AMI patients. Furthermore, the peak of serum CRP concentration was at 48 hours after onset of AMI.In AMI and SAP groups, there was a significant positive correlation between serum IGF - I and CRP levels ( r = 0. 503, p < 0. 01). Similar results are also generated from serum IGF - II and CRP levels ( r = 0. 584, p < 0.01) . The correlation was absent between serum IGF - I , IGF - II levels and CPK -MB ( p > 0. 05 ). Serum IGF - I was positively associated with serum IGF - II (r=0.642, p<0.01).ConclusionSerum IGF - I and IGF - II levels in AMI group increased significantly, and was higher than those in SAP and control groups. Serum IGF - I and IGF - II levels in SAP group were lower than those in control group. Serum IGF -I was associated with serum IGF - II , and they were not related to the measurement of CPK - MB.Similarly, serum CRP also increased obviously in AMI group, and was higher than that in SAP and control groups.There was a significant positive correlation between serum IGF - I , IGF -II and CRP levels in AMI and SAP groups.
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