The Expression And Significance Of Syndecan-1,E-cadherin In Breast Carcinoma

Background and Objective: Breast carcinoma is a malignant disease which seriously threates female health. The incidence of breast carcinoma accounts for the first position of female malignant tumors. Though the history of the treatement research of berast carcinoma has more than 100 years, especially in recent twenty years, the diagnosis and treatment technology of breast carcinoma have made great progress, but about 400 thousand female die of it all over the world every year. At present the research of the carcinogenesis and malignant progression of breast carcinoma still is a hotspot of breast carcinoma research. Researching deeply the mechanism of the carcinogenesis and development of breast carcinoma have important significance for the choice and implement of the treatment and prevention measures of breast carcinoma.In recent years, the studies about the function of adhesion molecules have gradually increased and validated their important significance in the carcinogenesis and development of the tumors. Syndecan-1, an important member of Syndecanfamily,is a transmembrane heparan sulfate proteoglycans cell adhesion molecule. Syndecan-1 binds a series of extracellular ligands via its covalently attached heparan sulfate chains, mediates cell-matrix,cell-cell adhesion,maintains the completion and stability of normal epithelia morphology and structure ; takes part in the carcinogenesis and development of the tumors by modulating cell proliferation, influencing cell migration. E-cadherin, epithelial cadherin, is a classical member of calcium dependant cadhesion molecule family. E-cadherin is one of the most important intercellular adhesion molecules of epithelia cell surface. E-cadherin maintains the epithelial polarity and the completion of normal epithelium morphology and structure by mediating the same intercellular adhesion response, possesses cell touching growth inhibition function and inhibits cellular isolation each other. E-cadherin is classical carcinogenesis /invasion inhibition gene of certain types of carcinomas.The expressions of Syndecan-1 and E-cadherin were decreased/lost in Ras transformed breast epithelia, which manifests the changes of tumorous morphology and biological functions. The expressions of Syndecan-1, E-cadherin significantly were decreased in epithelia carcinogenesis. The expressions of Syndecan-1, E-cadherin were significantly decreased in many human tumors and the decreased expression of Syndecan-1, E-cadherin in tumors significantly correlated with the clinical pathology features of patient with tumors. The expressions of both molecules manifestd a certain degree mutual dependence. All suggest the disorder/lose of functions of cell-matrix, intracellular adhesion and the likely abnormal message transduction duing to the decreased or loss expression of Syndecan-1, E-cadherin play important roles in carcinogensis and progression of tumors.At present, the documents reporting the relations of Syndecan-1 expression and the clinical pathology features of breast carcinoma are less. The research in the correlation of the expression of Syndecan-1 and E-cadherin in breast carcinoma tissue was not reported in documents all over the world. In this experiment, we investigated the expression conditions of Syndecan-1 and E-cadherin in breast ductal carcinomatissue and control normal breast tissue, fibroadenoma breast tissue by immunohistochemisty, and analyzed the respectively expression difference of Syndecan-1, E-cadherin among different breast tissues and between breast ductal carcinoma in situ and breast invasive ductal carcinoma tissues, the associations between the expressions of Syndecan-1, E-cadherin and the clinical pathology features of breast invasive ductal carcinoma tissues and the correlation between Syndecan-1 expression and E-cadherin expression in breast ductal carcinoma tissues.Discussing the roles of Syndecan-1 and E-cadherin in the carcinogenesis and development of breast carcinoma and the likely molecule mechanism to supply a experiment basis for introducing Synde...