Rosiglitazone Intervene The Multiple Facters Affecting Carotid Arterial Atherosclerosis In Type 2 Diabetes Mellitus

Objective To discuss the multiple facters affecting carotid arterial atheroisclerosis in type 2 diabetes mellitus and observe the therapy effect of rosiglitazone. Methods: Collected 110 cases with type 2 diabetes and examined their arterial wall thickness and local atherosclerosis in the carotid arteries (CAs) by B-mode ultrasonography of the CAs. According to the results of B-mode ultrasonography,the 110 cases were disparted for four groups:carotid arteries normal; carotid arteries incrassation; stabilization plaque and destabilization plaque. The limosis serum insulin,proinsulin,sVCAM-1,HbA1C,TC,TG,LDL-C,HDL-C,CRP and microalbuminuria were determined. The relationship between these factors and the grade of carotid arteries arteriosclerosis was analyzed. 30 cases were choosed in plaque group and these cases were therpyed by rosiglitazone for 8 weeks. Results: insulin,proinsulin, HbA1C,BMI,CRP and microalbuminuria were not of significant difference among four groups. The level of TC,TG,LDL-C,HDL-C and sVCAM-1were lower in normal group than those in other groups. Multiple linear regression showed that the grade of carotid arteries were correlated with age,TG,LDL-C and sVCAM-1. Conclusion:the level of sVCAM-1 was likely to be the marker of the diabetes' complicationï¼› rosiglitazone could decrease the level of sVCAM-1 and protect the heart and vascular in diabetes patients.