Expression And Clinical Significance Of Survivin In Transitional Cell Bladder Carcinoma

Invasion and metastasis are two important characters of malignant tumor,in two process,the apoptosis-inhibitory protein survivin play an important role. Purposes: To investigate the expression of survivin and its clinical significance in human transitional cell bladder carcinoma.Methods :Immunohistological chemistry method was used to detect survivin expression in 75 cases of bladder transitional cell carcinoma.The relationship between survivin expression and the clinicopathologic parameters, prognosis was retrospectively analyzed. Results: Survivin expression was not detected in healthy bladder mucosa.Survivin expression was positive in 35 of 75(46.7%).The survivin expression positive rate in grade I ,II and III tumors was 26.9(7/20) , 48.5%(16/33), 75.0%(12/16) and in stage Tis~T, and T2~T4 tumors being 34.2%(14/41) and 61.8%(21/34).The survivin expression positive rate in recurrent cases was 62.5%( 15/24) and in non-recurrent cases being 36.4%(16/44).The 5-year survival rate was 75.0%(51/68).The 5-year survival rate in patients with survivin positive expressed was 61.3%(19/31) and 86.5%(32/37) in patients with survivin negative expressed.The survivin expression positive rates were significantly higher in poorly differentiated andinvasive bladder cancer. Expression of survivin correlated well with histological grade -, clinical stage and prognosis. Conclusions:There was an important role of survivin expression in the development and for the progression of bladder cancer. Survivin expression could be used as a tumor marker for bladder cancer.