The Safety Of The Liquor Of Cultivating Zanglinggu And Its Effect Of Regulating Blood Lipid And Ameliorating Constipation

Objective: To study the safety of the liquor of cultivating Zanglinggu, and to observe its regulating function on human blood lipid and its curative effects on human constipation. Methods: firstly, some tests of acute oral toxicity, micronucleus of born marrow cell, sperm shape abnormality in mice and thirty- day feeding were conducted in order to assess the dangers on man. Secondly, Choosing 45 patients with constipation, then divided them into testing group, milk group and control group randomly. Testing group drank the liquor of cultivating Zanglinggu 4ml/kg and milk group drank equal quantity of milk before sleeping, to do so successively for 2 weeks, we mensurated the time between two defecation and the time of defecation on the time of beginning the test and end the test. Thiredly, Choosing 60 patients diagnosed with glycelipidemia, then divided them into testing group, milk group and control group randomly. Testing group drank the liquor of cultivating Zanglinggu 4ml/kg and milk group drank equal quantity of milk before sleeping, to do so successively for 20 day, we mensurated the serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) (use FRIEDEWALD equation), blood pressure on the time of beginning the test and end the test. Results: The liquor of cultivating Zanglinggu belonged to actually non-toxicity(LD50>22g/kg). Tests of micronucleus of born marrow cell, sperm shape abnormality in mice were negative. The thirty - day feeding test in mice demonstrated that it had no effect on routine blood, body weight, viscera coefficient, rate of using food and biochemical index. The tests of defecationon patients with constipation showed that the time between defecation was 3.43 ± 0.37 day, 1.73 ±0.73 day and the time of defecation was 10.73 + 2.12 minute, 6.80 + 2.27 minute at the beginning test and the end test on testing group. They both decreased significantly (P<0.05). But the milk group and control group showed no significant difference (P>0.05). After drinking the liquor of cultivating Zanglinggu the depressed number of the serum TC on testing group was significantly different compared with the milk group and control group (P>0.05) , but the serum TG, HDL-C, LDL-C showed no significant difference (P>0.05). Conclusion: The liquor of cultivating Zanglinggu is safety for man. Drinking the liquor of cultivating Zanglinggu can ameliorate human constipation and decrease the serum TC of patients with glycelipidemia.