The Change And Its Significance Of Serum Levels Of SFas,sFasL,NSE In Patients With Traumatic Brain Injury

OBJECTIVES: To explore the rule of neuron injury by investigating soluble Fas (sFas) , soluble Fas ligand (sFasL) and Neuron-specific enolase (NSE) in serum of patients with traumatic brain injury.METHODS: Selecting 35 cases of pure traumatic brain injury patients, dividing them into minor, moderate and severe three groups. Serum sFas, sFasL and NSE levels were measured in 24 hours, 72 hours , 7 days and 14 days with Enzyme Linked-Immune-Sobent Assay (ELISA) method.RESULTS: (1) Both sFasL and sFas were observed significant elevation in patients" serum, and reached climax about 72 hours after brain injury . (2) Elevation of serum NSE was also observed in 24 hours ,and the more severe the trauma ,the more significant the elevation . (3)Both sFas and sFasL correlate positively with NSE (r=0.841,0.847;p<0.01).CONCLUSIONS: (1) Primary and secondary neuron injury are existing after brain trauma. (2) The Fas/FasL system play an important role in secondary brain injury, sFas may prohibit neuron apoptosis in some extent. (3) Measuring serum sFas , sFasL can help us realize the degree of secondaryneuron injury and provide theoretical basis to explore new method of treatment in brain traumatic patients.