| Objective: To study the effects of Jiu xiang xin tong shu pill on the hemorheology , metabolism of lipoprotein , activated platelets and protecting and rehabilitating function of endothelium vessel of experimental rats with hyperlipidemia or hyperlipidemia and blood stasis ,so as to understand its mechanism .Methods: To feed hyperlipide feedstuff to engender rats with hyperlipidemia and hereon to hypodermic injecting adrenalin to rats and drop it into ice water to induce rats with both hyperlipidemia and blood stagnancy then to observe difference of hemrheology and metabolism of lipoprotein and activing degree of blood plate and serum level of NO .Result: Jiu xiang xin tong shu pill greatly decreased the whole blood viscosity (high-shear , middle-shear , low-shear) and plasm viscosity (p<0.05) , especially high dose had more effection than control trials in some degree . Its high dose had better effection on falling lipemia level, accelerating its metabolism ; mending endothelium vessel; promoting NO level (p<0.05). Conclusion: Jiu xiang xin tong shu pill regulates disorder of lipid metabolism ;depresses activated platelets ; mends endothelium vessel ; increases NO level and balances hemorheology by activating blood circulation to disspate blood stasis , activating QI and eliminating phlegm , and then realizes to removing both phlegm and blood stasis at the same time , and achieve preventing and staving appearance or course of AS and achieve the purpose of preventing and curing heart-brain vas disease.
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