Research Of The Relationship Between Gastric Carcinoma Traditional Chinese Medicine Classification Of Syndrome And Tumour's Invasion And Metastasis

Objection: In order to probe into the relationship between gastric carcinoma Traditional Chinese Medicine Classification of Syndrome and tumour's invasion and metastasis.Establish inherence touch between them. In the interst of discussion the essence meaning of Chinese Medicine classification of syndrome. Method: Getting across summarizing the previous literatures , on the basic of inducing gastric carcinoma Traditional Chinese Medicine classification of syndrome, gain the applied classifications of syndrome, according to clinical fact, then apply the classifications into the patiets we are researching. Twe Traditional Chinese Medicine doctors beyond attending go to the bedside to differentiate and conform the classification every patiet belonging to. Record the commonly datum relating to differentiate classification of syndrome in detail. Analyze the removal specimens in pathology, and exploring the ralationship between gastric carcinoma pathology type and classification of syndrome. Inspect the gene expression of all classifications of syndrome by the method of immunohistochemist, in order to judge the differences prone to invasion and metastasis among the 6 gastric carcinoma Traditional Chinese Medicine classifications of syndrome.Result and Conclusion: during the researching of the relationship between gastric carcinoma classification and tumour's invasion and metastasis, we discover that:1. Establishment of classification of syndrome: The result of summing-up of classification of syndrome is coincidence with the 6 classifications set down by Peking gastric carcinima cooperation group in the first gastric science congress in 1978. We according to the result to applying to the patiets. The six classifacations are discordance of liver and stomach, stagnation of phlegm-damp, obstruction of stasis and toxic, Yin-insufficiency due to stomach-heat, deficiency-cold of the spleen and stomach, insufficiency of qi and blood.2. Among 228 cases of gastric carcinoma patiens, advanced ones is 158, account for 69%, the ratio of each classification account for are as follow: discordance of liver and stomach 23.4%, deficiency-cold of the spleen and stomach 10.1%,obstruction of stasis and toxic 9.49%, Yin-insufficiency due to stomach-heat 8.86%, the type of stagnation of phlegm and qi 20.89, and insufficiency of qi and blood 14.56%, respectively. It make clear that gastric carcinoma is a kind disease that jeopardize humen's health heavily. When the patiens are treatment by surgery, we find that 69 per cent ones relate to metastasis which make it out that it is necessary and significant work to do the research on anti-metastasis.3. Our first research result suggest that there is partial relationship between gastric carcinoma Traditional Chinese Medicine classification of syndrome and pathology(1) Among mucous gland carcinoma there is difference between classification of syndrome and pathology. We compare every two classification, and draw the conclusion that obstruction of stasis and toxic more than discordance of liver and stomach(P=0.029<0.05), deficiency-cold of the spleen and stomach more than stagnation of phlegm-damp (P=0.022<0.05) , obstruction of stasis and toxictype more than stagnation of phlegm-damp type (P=0.001<0.01) .There is no significant between other groups.(2) Among signet-ring cell carcinoma: discordance of liver and stomach is more Yin-insufficiency due to stomach-heat type and insufficiency of qi and blood(P=0.019<0.05) , deficiency-cold of the spleen and stomach more than insufficiency of qi and blood (P=0.04<0.05), stagnation of phlegm-damp more than insufficiency of qi and blood (P=0.026<0.05) , discordance of liver and stomach more than insufficiency of qi and blood (P=0.035<0.05) .4. the research of the relation between the expression of Tumor metastatic genes and gastric carcinoma TCM classification of syndrome suggest:(1) The ratio of the protein expression of gastric carcinoma related genes is VEGF 94%, KDR 71%, C-erbB-2 77%, p53 6...