| Objective Cell adhesion molecules may serve as markers of endothelial cell activation, and they may well have a role in the pathogenesis of atherosclerotic vascular disease in diabetes mellitus. This aim of this thesis was to study variations of plasma sE-selectin and sICAM-1 level in type 2 diabetes patients and who was complicated with lower limb vascular pathological plaque formation, and the relationship between the two molecules and the course, blood pressure, blood lipid, insulin resistance, as well as the main index of renal function, hemodynamics parametes, UMA(urinary microalbumin) and TP(total protein). Methods Plasma sE-selectin and sICAM-1 of 51 type 2 diabetes patients , and 20 age, sex matched non-diabetes group (control group) were determined. 16 patients without lower limb vascular pathological plaque formation and 17 age, sex matched who with this complication were selected from the patients group, as group 1 and group 2 respectively, and 17 age, sex matched non-diabetes individuals selected from control group were selected from control group,as group 3, sE-selectin and sICAM-1 level were determined among the three groups. The correlation analysis between sE-selectin, sICAM-1 and general and other biochemical parametes were processed.Results (1) Level of FPG, P2PG, HOMA-IR, sE-selectin and sICAM-1 in diabetic group were significantly elevated compare to the control group (t value 14.250,17.746,3.564,3.118,4.357 respectively, p<0. 01). (2) HOMA-IR of group 2 was notably higher than group 1 (t=l. 24, p<0. 05) and group 3 (t=l. 51, p<0.01). sE-selectin, sICAM-1 and other parametes fail to had significance between group 1 and group 2(p>0. 05). FPG, P2PG of group 3 were markedly lower than the other two groups aboveabove(t=4.41 and 5.27, p<0.01), although FINS in group 3 was higher than group 2 and group 1, there was significant difference between with group l(t=3.76, p<0.05), HOMA-IR notably lower than group 2 (t=1.51, p<0. 01), sE-selectin markedly lower than group 1 (t=7. 00, p<0. 01), and sICAM-1 markedly lower than group 2 and group 1 (t=10. 13, p<0. 05, t=12. 02 p<0.01 respectively). (3) In non-diabetic group, though sE-selectin display positive correlation with sICAM-1, BMI, SBP, DBP, FPG, HOMA-IR, BUN, UA, TG and smoking amount, and negtively correlate with age, P2PG, FINS, CRE, CHO, HDL-C and LDL-C, there were no significance (p>0. 05), likewise, sICAM-1 showed positive correlation with BMI, P2PG, CRE, UA, HDL-C and smoking amount, and negtive correlation with age, SBP, DBP, FPG, HOMA-IR, BUN, TG, CHO and LDL-C, there were also no significant difference (p>0.05) . (4) In diabetic group, sE-selectin and sICAM-1 showed significantly positive correlation(r=0. 613, p<0.01), and positively relate to blood viscosity (p<0.05), negtively relate to age(r=-0. 316, p<0. 05), though nositive correlation showed with BMI, FPG, HbAlc, FMN, smoking amount, CHO, LDL-C, etc, negative correlation showed with TG, HDL-C, HOMA-IR, FINS, UNA and TP also, no significant difference appeared(p>0.05). At the same time, sICAM-1 positively correlate with DBP(r=0. 404, p<0. 01) , but had no significance positive relations with BMI, FPG, HbAlc, FMN, HDL-C, blood viscosity, HOMA-IR and FINS(p>0.05), and had no significance negative relations with age, smoking amount, TG, CHO, LDL, FIB, UMA and TP.* Conclusion 1. Plasma sE-selectin and sICAM-1 are elevated in type 2 diabetes compare to non-diabetic individuals, imply that endothelial dysfunction in type 2 diabetes. 2. Both type 2 diabetes patients with and without lower limb vascular pathological plaque formation have... |
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