Effects Of Wuqitongluo Capsule On The Activity Of Aldose Reductase And Nerve Conduction

[Objective] To investigate the effects of WuQiTongLuo capsule on nerve conduction Velocity,aldose reductase activity in diabetic rats.[Method] The model rats suffering from diabetes were induced by STZ ,and blood sugar level above 16.7mmol/L were investigated.The rats were divided into different groups; Nerve conduction velocity, Aldose reductase activity and morphology of nerve fibers were investigated.[Result] It was showed that WuQiTongLuo capsule was able to increase the sciatic nerve conduction velocity significantly ,with a lower of the sciatic nerve aldose reductase activity .RBC-sorbitol as blood sugar as compared with those of control groups.Morever, it could prevent the changes of never pathology.[Conclusion] The results suggested that WuQiTongLuo capsule was able to improve the nerve conduction velocity significantly and to reduce the aldose reductase activity in the earlier period.