Expression Of Cyclooxygenase-2 And Vascular Endothelial Growth Factor In Human Prostate Cancer And Its Significance

Objective: To evaluate the expression of Cyclooxygenase (COX-2) and VEGF in primary prostate cancer and its clinical significance. Methods: The expression of COX-2 and VEGF were detected by immunohistochemistry method in tissues of 40 prostate cancer and 10 benign prostatic hyperplasia samples. Results: COX-2 and VEGF levels in prostate cancer were much higher than those in BPH;the degree of cancer malignant and invasion positively correlated with the expression of COX-2 and VEGF;COX-2 level positively correlated with VEGF level. Conclusions: The abnormal expression of COX-2 plays an important role in the development of primary prostate cancer. COX-2 and VEGF are good molecular markers of prostate cancer which can be used to assist diagnosis and predict prognosis.