Expression Of Vascular Endothelial Growth Factor-c And Its Receptor VEGFR-3 In Hypopharyngeal Cancer Correlates With Lymphnode Metastasis

Objective:To investigate the relation between the expression of vaseular endothelial growthfactor-C(VEGF-C),its receptor VEGFR-3 and lymph metastasis in hypopharyngeal caneer.Methods:Immunohistochemistry methods were used to detect the expression of VEGF-C,VEGFR-3 in 34 eases of hypopharyngeal cancer(stage l,2.Ⅱ,6:Ⅲ,8;IV,18)and 19 eases of normal hypopharyngeal mucosa.Results:The Protein expression Percent of VEGF-C in hypopharyngeal cancer is 64.71%.The expression Percent of normal mucosa epithelium is 21.05%.The expression Percent of VEGFR-3 in vessel endothelial cells in hypopharyngeal cancer Tissue is 15.78±5.45,The expression Percent of normal mucosa epithelium is 9.04士5.83.There is Positive correlation between VEGF-C in hypopharyngeal cancer tissue and VEGFR-3 in vessel endothelial eells of hypopharyngeal cancer tissue.VEGF-C/VEGFR-3 expression was morer frequently found in tumors with lymphnode metastasis than in those Without it.VEGF-C expression In vessel endothelial cells with lymphatic invasion were significantly greater than those in tumors without lymphatie invasion.The study showed significant correlation between VEGF-C and MVD in hypopharyngeal cancer tissue.No dieffrence in age,stages betweenVEGF-C expression Positive group and negative group.There was uncertainly dieffrence in survival between VEGF-C expression Positive group and negative group.Conclusions:In hypopharyngeal cancer, VEGF-C/VEGFR-3 Play an important role in lymph invasion metastasis. The overexPression of VEGF-C/VEGFR-3 maybe helpful to Prognosticate the frequeney of regional lymPhnode metastasis and Prognosis in hyPoPharyngeal cancer.