The Effect Of Erythrocyte Chemokine Receptor On The Relationship Between Innate And Acquired Immunity In Patients With Psoriasis

To determine the expression of erythrocyte chemokine receptor (ECKR) on peripheral blood Red blood cells (RBCs), neutrophils and T lymphocytes of patients with psoriasis and to explore its effect on the relationship between innate and acquired immunity in patients with psoriasis. The experession of ECKR on peripheral blood RBCs, neutrophils and T lymphocytes from psoriatic patients and healthy controls was detected by flow cytometry and RT-PCR technique. The correlation between ECKR and psoriatic aera and severity index (PASI) was evaluated. The expression of ECKR protein on RBCs, neutrophils and T lymphocytes from psoriasis vulgaris patients were decreased compared with healthy controls. Enhanced expression level of ECKR mRNA could be seen in RBCs, neutrophils and T lymphocytes derived from the psoriasis vulgaris patients. The present study suggested that the expression of the ECKR on RBCs, neutrophils and T lymphocytes in the patients with psoriasis is significantly altered and is related with the disease progress. ECKR could play some effects on the pathogenesis of psoriasis and on the cooperation between the innate immunity and the acquired immunity.