The Effect Of Weilingchongji On IL-2 And THF In Rats With Chronic Atrophic Gastritis

Objeqtive:To observe the effect of WeiLingChongJi (WLCJ) on the gastric mucosa level of IL-2, TGF and gastric mucosa pathological histology in rats model of Chronic Atrophic Gastritis, and to explore the mechanism of WingLingChongJi in the treatmont of CAG.Methods: One hundred male Wistar rats were randomly divided into five groups: normal control group, model group, WeiMeiSu control group, low-dose WLCJ group and high-dose WLCJ group. Except normal control group rats, CAG model was established in other rats by synthetical method: 2% salicylas and 55℃ hot water which contained 150g/L Nacl were given orally once a day, and 20mmol/L sodium deoxycholate was drunk freely, as they are overeating and hungering, all the factors were given for ninety days. When the model was established successfully, all rats were treated with different medicines, after a month, all the rats were sacrificed, their gastric mucosa and stomaches were collect to detect the gastric mucosa level of IL-2 and TNF and observe the histologic mucosa changes by microscopy.Results: Compared to normal control group, the gastric mucosalevel of IL-2 and TNF in the rats of model group was significantly lower(P<0. 01),and the pathologic changes were significant , but after the model rats were treated with high-dose WLCJ for a month, the gastric mucosa level of IL-2 and TNF were recovered, and signifcant statistics difference in pathologic changes of gastric mucosa was...