Clinical Study Of Valproate (VPA) On Glycometabolism In Children With Epilepsy

Objective To determine the effect of VPA on glycometabolism in children with epilepsy by observing the change of weight, BMI, blood glucose, insulin and insulin resistance(IR) after VPA mono-therapy. Methods 45 normal children were selected as the control group. 45 cases with VPA mono-therapy in future were included as the observation group I, and the observation group II was that whose patients were treated with VPA mono-therapy for 3 months, while the observation group III were those who had been treated with VPA for 6 months. Body weight, BMI, blood glucose, insulin and IR index were separately detected. Results 1.Compared the control group with the observation group I, II, III, body weight was 17.23±4.10(kg),16.75±3.89(kg),20.57±5.53 (kg),22.23±4.69(kg) respectively; BMI was 18.45 ±2.36(kg/m~2),18.75 ±2.94(kg/m~2),20.98±2.42(kg/m~2),21.46±3.36 (kg/m~2) respectively; the serum of glucose was 4.35 ±0.37(mmol/L),4.43 ±0.42(mmol/L),3.54 ±0.36(mmol/L),3.79±0.51(mmol/L) respectively; insulin level was 4.88±1.34 (mU/L),4.41±2.02(mU/L),7.73±3.44(mU/L), 6.45±4.11(mU/L) respectively; IR index was 0.91±0.14,0.98±0.21,1.10±0.17,1.07±0.23 respectively. 2. There was no difference among the changes of weight, BMI, blood glucose, insulin and IR index comparing the control group with the observation group I, II, III(P>0.05). Compared the observation group I with II, there was a significant increase of weight, BMI, insulin(P<0.01), and blood glucose fell(P<0.05), but no changes of IR index(P>0.05). Compared the observation group I with III, there was a significant increase of weight, BMI, insulin(P<0.01), but no changes of blood glucose, IR index(P>0.05). Compared the observation group II with III, there was no significant difference of weight, BMI, blood glucose, IR index(P>0.05), whereas insulin level was increased(P<0.05). Food appetite added Compared the control group with he observation group I, II, III(P<0.05). Conclusion VPA mono-therapy can raise the food appetite and body weight, and lower the fasting glucose, and lead to hyperinsulinemia in children with epilepsy, especially in the first 3 months after VPA being prescribed,but insulin resistance did not exist. These changes were mutually affected.