Epilepsy One Pentylenetetrazol Kindled Chronic Epilepsy Model In Rat Epilepsy Sex, Hippocampal Expression Of Gaba And Glu And Impact Studies, And Clinical Effect

OBJECTIVE:Through the observation of epilepsy on the ist of chronic epilepsy Pentylenetetrazol-induced changes in behavior and hippocampalGABA,GLU expression of the impact of epilepsy on the ist of Pentylenetetrazol-induced chronic anti-epileptic seizures in rats and its mechanismMETHODS:SD 120 adult rats,weighing 200-250g,were divided into six groups:normal,epilepsy model group,carbamazepine therapy group,epilepsy on the lst of high dose treatment group,on the lst of epilepsy dose treatment group,on the ist of epilepsy Low-dose treatment group,the groups are 20,male and female Geban.Pentylenetetrazol-use(PTZ) intraperitoneai injection (ip) model law,the dose by dose-convulsion 37.5mg/kg standard, a series of injections 28 days.Seven days after stopping for the same dose intraperitoneal injection of five days,changed every three days after an abdominal injection.Modeling success, the treatment group with epilepsy on the ist gavage for 28 days, the normal group and epilepsy model conventional farming. Observed in the test rats behavior changes,the final preparation of specimens from the hippocampus,each of GABA in the rat hippocampus and the GLU integral optical density.RESULTS:①High dose of Chinese medicine and western medlcine treatment group four weeks after a 4-5-1-3 onset of epilepsy significantly reduced in the low dose group of Chinese medicine treatment four weeks after the 1-3 grade seizures,no reduction of the number,4-5-but seizures have decreased remarkably,only one;frequency of epileptic seizures model group before and after the treatment had no significant changes in the normal group of no change.The treatment group could GLU significant downward adjustment in the expression of GABAincreased the expression of these changes on the lst of epilepsy treatment of high-dose group and the role of intensity similar to carbamazepine,GABA and GLU on the lst of expression in epilepsy between the different dose groups showed Dose-effect relationshipCONCLUSION:①on the ist of epilepsy can control the seizures.②GLU lowered the expression,the expression may increase GABAis the role of epilepsy on the ist OBJECTIVE:Epilepsyon the Ist through thejoint treatment of valproate sodium valproate alone with God permit interference Tanhuo absence epilepsy seizures of comparative observation,evaluation of epilepsy treatment is Tanhuo interference on the lst of Godpermits epileptic seizures absence of efficacyand safety ofMETHODS:According to rule out the standards included in the choice of absence seizures and epilepsy TCM is a disturbing Tanhuo God Syndrome cases of 40 patients,randomized balloting method,divided into 20 cases of the treatment group and control group of 20 cases, the use of epilepsy treatment group on the ist Joint Sodium valproate treatment,a separate control group of sodium valproate treatment courses are in March,the two groups were observed in patients with epilepsy beforeand after the onset of the number of Chinese medicine syndrome,EEG changes and securityRESULTS:①two epileptic seizures absence effects of the disease: The total efficiency of 80 per cent,the total efficiency of the control group was 75 percent,compared no difference between the two groups P＞0.05;②between the two groups of Chinese medicine syndrome effects show:The total efficiency of 85 per cent of the control group,the total efficiency of 45 percent, were testing the effect of P＜0.05,a sta(?)istically significant;③Chinese medicine shows signs of a points compared treatment Before and after treatment of Chinese medicine are obvious signs integral changes,the group more significant statistical significance,P＜0.05;control group before and after the treatment showed no statistical significance,P＞0.05; ④two groups improved after treatment EEG meaningful comparison,P＜0.05;⑤treatment Group 20 cases of patients, one of the fasting patients on medication found that mild abdominal discomfort,no other adverse reactions.The two groups were randomly Gequl0 people before and after treatment to blood, urine routine and liver and kidney function tests,are not unusual,the two drugs have had good security.CONCLUSION:①epilepsy on the ist Joint valproate treatment of epilepsy absence seizures Tanhuo nuisance God permits shown more effective than pure sodium valproate trend.②epilepsy on the Ist Joint valproate treatment of epilepsy found no obvious side effects.