The Effects Of The Sand Therapy Of Uyghur Medicine On The Rabbit Experimental Knee Osteoarthritis

Objective: To study the effects of the sand therapy of Uyghur medicine on the rabbit experimental knee osteoarthritis. Methods: A well established model of osteoarthritis induced in rabbit knee joint by injection EMK into the joint space of right knee, then the animals was divided randomly into three groups: Beginning from the 15th day after the articular injection, the rabbits of I group was treated with the sand therapy once every day ; the rabbits of II group was treated with fenbid once every day; and III group, there was no treatment for the blank control group .At the end of the experiment, the serum and the synovial fluid of the diseased joints were obtained for the testing of IL-1B, TNF-α, NO; the cartilage was obtained for the measure of the histopathology. Results: Compare with the fenbid group and the blank control group, the severity of the cartilage in the sand therapy group declined significantly; The IL-1β, TNF-α level of the sand therapy group and fenbid group in synovial fluid and NO level in serum of the sand therapy were decreased significantly; Conclusions: The sand therapy give a play to treatment in osteoarthritis, this effect is related to the decreasing of cytokine in the local joints.