The Changed Number Of Mast Cells In Affected Intestinal Mucosa Of Patients With Ulcerative Colitis And The Relations With Clinical Parameters

ObjectiveTo investigate the number changes of mast cells in intestinal mucosa of patients with ulcerative colitis and the relations with age, sex or the location of affected intestinal mucosa .Materials and methodsSamples from 50 ulcerative colitis patients and 50 controls were studied by immunohistochemical staining (SP). The clinical diagnosis of ulcerative colitis was confirmed by the routine radiologic, endoscopic and histologic criteria. Intestinal mucosa from all controls are normal as confirmed by colonoscopy and histological evaluation.ResultsMast cell were dyed dark brown granulation when observed with light microscope. The number of mast cells in affected intestinal mucosa of UC increased significantly as compared with that of controls (t =6.22,P<0.001). There was no significant difference between groups of age > 40 and age < 40 ( t =0. 65 , P=0.21 > 0.05), and groups of male and female (t=0.65, P=0.23 > 0. 05 ) . There was no significant difference between rectum and sigmoid colon (t = 1.25, P=0.22 > 0.05) or between sigmoid colon and descending colon (t = 1. 20, P = 0. 24 > 0. 05 ) . But the number of mast cell in rectum was more thanthat in decending colon (t = 2. 15 , P =0. 044 < 0.05).ConclusionMast cell in affected intestinal mucosa of UC was obviously increasing, and it' s more frequent in rectum than that in descending colon in UC. It implies that mast cell play important role in UC and provides a new method and prospect.