Study On The Risk Factors Of HUM Among Males And Related Gene Polymorphisms Analysis

Objective: to analyze relationship of hyperuricemia and biochemicals and dietary,lifestyle and MTHFR, β₃-AR, ACE, AGT gene polymorphism ,explore the risk factors for hyperuricemia among males and prevent and treat hyperuricemia effectively. Methods: A case-control study was conducted with 200 males cases of hyperuricemia and 286 males as controls. Anthropometric, blood pressure and biochemical variable were measured and dietary,lifestyle and disases history were conducted face-to-face investigation. Random select 98 cases and 81 controls detected MTHFR C677T polymorphism, β₃-AR T190C polymorphism, ACE I/D polymorphism and AGT T704C polymorphism by DNA microarray technology . Results: 1) Compared to normouricemic subjects, hyperuricemic subjects had significantly greater body mass index and WHR, higher blood pressure and glucose and blood lipid concentrations (p<0.001). In multivariate correlation analyses, SUA concentration was significantly positively associated with BMI, WHR, serum total cholesterol and triglyceride concentrations (r>0.4, P<0.001). Hyperuricemic subjects had significantly higher frequency of obesity, hypertension and dyslipidemia (P<0.01). 2)Compared to the control, hyperuricemia consumed more beer,wine, purine and cigarette smoking (P <0.05), frequency of hyperuricemia increased with increasing purineor beer intake. 3) The frequency of MTHFR T allele amone the cases(50.5%) was significantly higher than the controls (38.8%) (P=0.028), the odds ratios for hyperuricemia was 1.617. Uric acid, triglyceride concentrations and body mass index were remarkabley higher in subjects with TT genotype than in subjects with CC genotype (P< 0.05). 4) Logistic regression analyses showed that BMI, DBP, TG, Glu, high Beer intake and purine intake were the risks of hyperuricemia. Conclusion: 1) Obesity, hypertension, dyslipidemia and arteriosclerosis were closed related to hyperuricemia. 2) Beer, wine, purine and cigarette smoking played a significant role in increasing serum uric acid level. 3) MTHFR C677T mutation may be considered a risk factors for hyperuricemia in Chinese males. 4) Weight controlling, lowing lipids, lowing blood pressure are necessary when prevention and treating hyperuricemia and treatment of hypertension, dyslipidemia or arteriosclerosis need keep normal serum uric acid level. Prevention and treating hyperuricemia should decrease the intaking of alcohol, purine and cigarette smoking.