Pharmacodynamics And Pharmacokinetics Of High Concentrations Propofol In Rabbits

Propofol (2,6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is an oil at room temperature and insoluble in aqueous solution. Present formulations consists of 1% (w/v) propofol, 10% soybean oil, 2.25% glycerol, and 1.2% egg phosphatide. Disodium edetate (EDTA) or metabisulfite is added to retard bacterial and fungal growth. Some cases suggest that high-dose,long-term propofol infusion for sedation of patients in the intensive care unit can result in metabolic acidosis, hypertriglyceridemia, hepatomegaly, rhabdomyolysis, acute renal failure, hyperkalemia, ventricular arrhythmia, and cardiac failure wich has been referred to as propofol infusion syndrome (PIS).Critically ill patients may have altered metabolic and enzyse system such that they might not be able to handle an excessive fat load that would be given during prolonged infusions of propofol,which may aggravated the lipid load and the disorders of lipid metabolism and even caused the hypertriglyceridemia. In order to avoid the potential for elevated serum lipid levels as a consequence of long term sedation with propofol,high concentrations of pfopofol(2%,5%) has been developed,which would reduce the lipid load compared with the present 1% formulation.This study compared the pharmacodynamics and pharmacokinetics of propofol 2% and 5% with 1% formulation in rabbits and compared their...